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18-methoxycoronaridine

a naturally-occurring iboga alkaloid; structure given in first source

Also Known As:

18-MC compound; ibogamine-18-carboxylic acid, 21-methoxy-, methyl ester

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Glick, Stanley D: 6 articles (06/2011 - 07/2002)
2.	Maisonneuve, Isabelle M: 5 articles (06/2011 - 07/2002)
3.	Taraschenko, Olga D: 4 articles (06/2011 - 07/2007)
4.	Lavaud, Catherine: 1 article (01/2017)
5.	Massiot, Georges: 1 article (01/2017)
6.	Hathaway, Ethan R: 1 article (05/2011)
7.	McCallum, Sarah E: 1 article (05/2011)
8.	Vincent, Melanie Y: 1 article (05/2011)
9.	Shulan, Joseph M: 1 article (07/2007)
10.	Priebe, Stefan: 1 article (02/2006)

Related Diseases

1.	Weight Gain 06/01/2011 - "In previous studies from this laboratory, a high sucrose diet induced excessive weight gain in female but not in male Sprague-Dawley rats, while weight gain in both sexes was similarly attenuated by the administration of a selective antagonist of α3β4 nicotinic receptors, 18-methoxycoronaridine (18-MC). " 02/01/2011 - "In previous studies from this laboratory, a high sucrose diet induced excessive weight gain in female Sprague-Dawley rats and administration of a selective antagonist of α3β4 nicotinic receptors, 18-methoxycoronaridine (18-MC), prevented this form of obesity. "
2.	Obesity 06/01/2011 - "Sex differences in high fat-induced obesity in rats: Effects of 18-methoxycoronaridine." 02/01/2011 - "Resistance of male Sprague-Dawley rats to sucrose-induced obesity: effects of 18-methoxycoronaridine." 05/01/2011 - "18-methoxycoronaridine (18-MC), a selective antagonist of α3β4 nicotinic receptors, has been previously shown, in rats, to reduce the self-administration of several drugs of abuse, reduce operant responding for sucrose, and prevent the development of sucrose-induced obesity. " 02/01/2011 - "In previous studies from this laboratory, a high sucrose diet induced excessive weight gain in female Sprague-Dawley rats and administration of a selective antagonist of α3β4 nicotinic receptors, 18-methoxycoronaridine (18-MC), prevented this form of obesity. "
3.	Substance-Related Disorders (Drug Abuse) 07/01/2007 - "18-Methoxycoronaridine (18-MC), a novel iboga alkaloid congener, is a potential treatment for drug addiction. " 06/01/2003 - "18-Methoxycoronaridine (18-MC), a novel iboga alkaloid congener that decreases drug self-administration in several animal models, may be a potential treatment for multiple forms of drug abuse. " 07/19/2002 - "18-Methoxycoronaridine, a novel iboga alkaloid congener that decreases drug self-administration in several animal models, may be a potential treatment for multiple forms of drug abuse. " 04/01/2000 - "Ibogaine and 18-methoxycoronaridine are naturally occurring alkaloids reported to possess antiaddictive properties in several models of drug dependence. "
4.	Schizophrenia (Dementia Praecox) 02/01/2006 - "The evidence is less conclusive for the use of omega-3 fatty acids as augmentation treatment in schizophrenia, melatonin for tardive dyskinesia and 18-methoxycoronaridine, an ibogaine derivative, for the treatment of cocaine and heroin addiction. "
5.	Opioid-Related Disorders (Opiate Addiction) 10/21/1999 - "Together, the microdialysis and self-administration data suggest that 18-methoxycoronaridine profoundly alters mechanisms crucial to the development and maintenance of opioid addiction."

Related Drugs and Biologics

1.	Sucrose (Saccharose)
2.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
3.	Alkaloids
4.	Ibogaine (Endabuse)
5.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)
6.	Melatonin
7.	Cocaine (Cocaine HCl)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)