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dehydrocrotonin

a 19-nor-clerodane diterpene; isolated from the bark of Croton cajucara; structure given in first source

Also Known As:

trans-dehydrocrotonin

Networked: 9 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Clerodane Diterpenes: 48
        dehydrocrotonin: 9

Experts

1.	Durán, Nelson: 3 articles (10/2004 - 01/2003)
2.	Haun, Marcela: 3 articles (10/2004 - 01/2003)
3.	Melo, Patricia S: 2 articles (10/2004 - 03/2004)
4.	Cardoso, Evani Ferreira: 1 article (11/2021)
5.	Da Silva Mota, Gunar Vingre: 1 article (11/2021)
6.	Giacomello, Thaís Forest: 1 article (11/2021)
7.	Paranhos Costa, Fabio Luiz: 1 article (11/2021)
8.	Rocha de Oliveira, Leandro Leal: 1 article (11/2021)
9.	Souza Siqueira, Marcelo Ricardo: 1 article (11/2021)
10.	da Silva, Tiago Arouche: 1 article (11/2021)

Related Diseases

1.	T-Cell Lymphoma (Lymphoma, T Cell) 03/08/2004 - "Investigation of the effects of dehydrocrotonin treatment on total natural killer (NK) cell activity of tumour-bearing mice as a possible mechanism of dehydrocrotonin action in vivo revealed that this sesquiterpene lactone significantly improved NK cytotoxicity against YAC-1, a Moloney virus-induced mouse T-cell lymphoma of A/SN origin. "
2.	Leukemia 01/01/2003 - "Cytotoxic effect of the diterpene lactone dehydrocrotonin from Croton cajucara on human promyelocytic leukemia cells." 10/15/2004 - "In this study, we examined the mechanisms of apoptosis induced by dehydrocrotonin (DHC), a diterpene lactone isolated from the Amazonian plant Croton cajucara, and its synthetic derivative, dimethylamide-crotonin (DCR), in human HL60 promyelocytic leukemia cells. "
3.	COVID-19 11/01/2021 - "A Combined Molecular Docking and Density Functional Theory Nuclear Magnetic Resonance Study of Trans-Dehydrocrotonin Interacting with COVID-19 Main Protease and Severe Acute Respiratory Syndrome Coronavirus 2 3C-Like Protease."
4.	Stomach Ulcer (Gastric Ulcer) 03/01/1998 - "trans-Dehydrocrotonin (DHC), the major diterpene isolated from Croton cajucara Benth, was assayed for antiulcerogenic activity in four induced gastric ulcer models in the rat. "
5.	Sarcoma 180 12/01/1999 - "The effects of two nor-diterpenes, trans-dehydrocrotonin (DCTN) and trans-crotonin (CTN) from Croton cajucara (Euphorbiaceae), on the survival of mice bearing Sarcoma 180 and Ehrlich carcinoma ascitic tumours, on the proliferation of cultured Ehrlich cells and TNF alpha activity were determined. "

Related Drugs and Biologics

1.	Lactones
2.	Sesquiterpenes
3.	Diterpenes
4.	Peptide Hydrolases (Proteases)
5.	dimethylamide-crotonin
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Carrageenan
8.	trans-crotonin (CTN)