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2-(3-ethylureido)-6-methylpyridine
a potent inducer of cell differentiation
Also Known As:
UDP 4; UDP-4
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
2-(3-ethylureido)-6-methylpyridine: 2
Organic Chemicals: 133
Amides: 2428
Urea: 15015
2-(3-ethylureido)-6-methylpyridine: 2
Related Diseases
1.
Rhabdomyosarcoma
06/01/1996 - "
Since the human TE-671 cell lines has been re-identified as a rhabdomyosarcoma (RD) rather than a medulloblastoma due to the presence of muscle-type nicotinic acetylcholine receptors, we re-investigated the nature of RD/TE-671 cells and characterized their differentiation induced by 2-(3-ethylureido)-6-methylpyridine (UDP-4), a potent inducer of differentiation of neoplastic cells.
"
2.
Medulloblastoma
06/01/1996 - "
Since the human TE-671 cell lines has been re-identified as a rhabdomyosarcoma (RD) rather than a medulloblastoma due to the presence of muscle-type nicotinic acetylcholine receptors, we re-investigated the nature of RD/TE-671 cells and characterized their differentiation induced by 2-(3-ethylureido)-6-methylpyridine (UDP-4), a potent inducer of differentiation of neoplastic cells.
"
3.
Acute Erythroblastic Leukemia (Erythroleukemia)
04/01/1992 - "
Five of these lipophilic compounds [2-(3-ethylureido)-pyridine (1), 2-(3-ethylureido)-6-methylpyridine (4), 2,6-bis-(3-ethylureido)-pyridine (7), 2-(3-ethylureido)-5-methylpyridine (14) and 2-(3-ethylureido)-4,5-dimethylpyridine (15)], promoted terminal erythroid maturation of murine erythroleukemia cells (MEL) (95% hemoglobin producing cells) and stimulated hemoglobin synthesis at concentrations as low as 0.075-0.5 mM. These concentrations are 50-70 fold lower than the optimum inducing concentration of hexamethylene bisacetamide (HMBA), a potent known inducer of differentiation.
"
Related Drugs and Biologics
1.
Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
2.
Hemoglobins (Hemoglobin)
3.
pyridine
4.
hexamethylene bisacetamide (HMBA)