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bis((3- (aminoiminomethyl)phenyl)methylene)carbonimidic dihydrazide trihydrochloride

structure given in first source

Also Known As:

CGP 40215; CGP 40215A; CGP-40-215; CGP-40215; CGP-40215A; CGP40215

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - Robenidine: 29
      - bis((3-(aminoiminomethyl)phenyl)methylene)carbonimidic dihydrazide trihydrochloride: 2

Related Diseases

1.	Central Nervous System Infections (Central Nervous System Infection) 06/01/1996 - "In addition, CGP 40215A also cured a model central nervous system infection in combination with the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine (DFMO; Ornidyl, eflornithine). "
2.	Infections 06/01/1996 - "One agent, CGP 40215A, a bicyclic analog of MGBG which also resembles the diamidines diminazene (Berenil) and pentamidine, was curative of infections by 19 isolates of Trypanosoma brucei subspecies as well as a Trypanosoma congolense isolate. "
3.	Adenocarcinoma 06/01/1996 - "This compound had a 50% inhibitory concentration of 0.0045 microM for Trypanosoma brucei rhodesiense, was also active against other trypanosome species, including a multidrug-resistant Trypanosoma brucei brucei, and was significantly less toxic than other compounds tested for a human adenocarcinoma cell line, with a 50% inhibitory concentration of 1.14 mM. The effect of CGP 40215A was time and dose dependent, and low concentrations of the compound required exposure times of > 2 days to exert trypanocidal activity. "

Related Drugs and Biologics

1.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
2.	Eflornithine (Ornidyl)
3.	Pentamidine (NebuPent)
4.	Mitoguazone (MGBG)
5.	Diminazene
6.	diminazene aceturate