voriconazole (Vfend)

05/01/2015 - "nidulans infections could be treated effectively with the standard dosage regimen; for extensive metabolizers (EM), the standard voriconazole dosage regimen failed to achieve the best outcome for the six Aspergillus spp. Increasing dose (e.g. "
01/01/2009 - "Treatment with the combination of an antifungal agent, mainly voriconazole, and surgery, when feasible, probably provide the best results in cutaneous infections."
01/01/2014 - "More patients died in the voriconazole group and a claimed significant reduction in the number of breakthrough fungal infections disappeared when patients arbitrarily excluded from the analysis by the trial authors were included. "
01/01/2011 - "Given its good CNS penetration, voriconazole along with surgical resection appears to be promising in treatment of these infections. "
01/01/2006 - "More patients died in the voriconazole group and a claimed significant reduction in the number of breakthrough fungal infections disappeared when patients arbitrarily excluded from analysis by the authors were included. "

03/01/2010 - "The patient showed remarkable improvement with voriconazole suggesting aspergillosis. "
02/01/2004 - "Voriconazole currently offers the best prospect for success and tolerance as a first-line treatment for aspergillosis. "
06/01/2005 - "According to a randomised trial, voriconazole has added a significantly improved therapeutic option for primary therapy of invasive aspergillosis. "
09/01/2008 - "Clinical application of voriconazole for the treatment of aspergillosis in birds appears to be promising, because this drug has a high effectiveness and wide tissue distribution, and long-term treatment did not cause clinical signs of adverse effects or organ damage in chickens."
10/01/2007 - "Invasive tracheal aspergillosis treated successfully with voriconazole: clinical report and review of the literature."

06/01/2014 - "To demonstrate that ultraviolet-A (UV-A) and voriconazole combination therapy is more effective than voriconazole single treatment for fungal keratitis. "
07/01/2015 - "Voriconazole spreads well in the eye and is effective in the cure of fungal keratitis including those caused by Alternaria."
04/01/2012 - "Intracameral and topical voriconazole may be effective against deep fungal keratitis presenting with endoexudates."
01/01/2012 - "Voriconazole was effective in treating this refractory keratitis."
06/01/2009 - "The voriconazole 1% eye drop used alone is a promising, cost-effective, safe option for managing fungal keratitis, even that caused by S. "

07/01/2009 - "Though fungal endophthalmitis has been successfully treated with a combination of intravenous and intravitreal voriconazole, to the best of our knowledge this is the first report in ophthalmic literature (Medline Search) on the treatment of fungal endophthalmitis with only the oral route of administration of voriconazole."
10/01/2011 - "To investigate the therapeutic efficacy and optimal drug dose of an intravitreally implantable voriconazole (VCZ) drug delivery system (DDS) in experimental endophthalmitis of Aspergillus fumigatus. "
01/01/2009 - "This case report shows that intravitreal voriconazole, in addition to topical and systemic treatment, was safe and very effective in treating Aspergillus endophthalmitis. "
07/01/2009 - "Use of voriconazole in the surgical management of chronic postoperative fungal endophthalmitis."
02/01/2015 - "Based on this laboratory study of isolates from exogenous fungal endophthalmitis, intravitreal voriconazole appears to provide the broadest spectrum of antifungal coverage and, as such, may be considered for empiric therapy of endophthalmitis caused by yeast or mold."

12/01/2011 - "Considering these facts, the authors report a clinical case of invasive pulmonary aspergillosis which illustrates the improved outcomes associated with the extended-spectrum triazole, voriconazole, used in first-line therapy."
12/01/2008 - "A 74-year-old woman given a diagnosis of chronic necrotizing pulmonary aspergillosis in February, 2007 was treated by intravenous voriconazole (VRCZ) and her conditions improved. "
05/01/2000 - "Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model."
06/01/2015 - "The present research aimed to develop and characterize a sustained release dry powder inhalable formulation of voriconazole (VRZ) for invasive pulmonary aspergillosis. "
04/01/2015 - "Autoinduction of voriconazole metabolism in a child with invasive pulmonary aspergillosis."