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GKLF protein

Subscribe to New Research on GKLF protein

putative negative regulator of cell growth; RefSeq NM_004235 (human); NM_010637 (mouse); NM_053713 (rat)

Also Known As:

EZF protein; EZF protein, human; GKLF protein, human; GKLF protein, rat; Gklf protein, mouse; KLF4 protein, human; Klf4 protein; Klf4 protein, mouse; Klf4 protein, rat; Kruppel-like factor 4; Kruppel-like factor 4 (gut), human; Kruppel-like factor 4 (gut), mouse; Kruppel-like factor 4 (gut), rat; endothelial Kruppel-like zinc finger protein; endothelial Kruppel-like zinc finger protein, human; epithelial zinc finger protein; gut-enriched Kruppel-like factor

Networked: 65 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Transcription Factors: 20597
    - Kruppel-Like Transcription Factors: 8
      - GKLF protein: 65
  - DNA-Binding Proteins: 1111
    - Kruppel-Like Transcription Factors: 8
      - GKLF protein: 65

Experts

1.	Xie, Keping: 4 articles (09/2012 - 04/2005)
2.	Wei, Daoyan: 3 articles (09/2012 - 04/2005)
3.	Liu, C: 2 articles (01/2014 - 01/2014)
4.	Fu, J: 2 articles (01/2014 - 05/2011)
5.	Huang, S: 2 articles (01/2014 - 05/2011)
6.	Ai, W: 2 articles (01/2014 - 05/2011)
7.	Chen, Chih-Jung: 2 articles (12/2013 - 04/2012)
8.	Lin, Shu-Hui: 2 articles (12/2013 - 04/2012)
9.	Jia, Zhiliang: 2 articles (09/2012 - 06/2008)
10.	Le, Xiangdong: 2 articles (09/2012 - 06/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "Kruppel-like factor 4 (KLF4) induces tumorigenesis or suppresses tumor growth in a tissue-dependent manner. " 01/01/2015 - "Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival." 01/01/2013 - "Epithelial-like MM189 PB-Klf4 and BL322 PB-Klf4 cells were generated from tumor suppressive Kruppel-like factor 4 (Klf4)-expressing mesenchymal-like MM189 and BL322 cells. " 12/01/2012 - "SPARC expression was increased in the tumor specimens compared with the control tissue (70.8% vs 7.9%, P<0.05), whereas KLF4 protein was reduced compared with that in the control tissue (42.7% vs 88.8%, P<0.05). " 05/05/2011 - "Kruppel-like factor 4 (KLF4) is highly expressed in more than 70% of breast cancers and functions as an oncogene. "
2.	Colonic Neoplasms (Colon Cancer) 07/01/2008 - "5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells." 04/27/2001 - "Studies from this laboratory have shown that GKLF protein predominantly expressed in the cytoplasm but not the nucleus of colon cancer cells, suggesting that impaired nuclear translocation of GKLF might contribute to cancer formation. " 11/29/2002 - "Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells." 02/01/2005 - "Forced expression of Hic-5 in colon cancer cells enhances the PPARgamma-mediated induction of several gut epithelial differentiation/maturation markers such as L-FABP, kruppel-like factor 4 (KLF4), and keratin 20. " 11/01/2005 - "15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells."
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2014 - "To investigate the association of Kruppel-like factor 4 (KLF4) expressions with the prognosis of esophageal squamous cell carcinoma (SCC) patients. " 01/01/2014 - "Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients." 06/01/1999 - "Expression cloning identified the major transforming activities in squamous cell carcinoma cell lines as c-MYC and the zinc finger protein gut-enriched Kruppel-like factor (GKLF)/epithelial zinc finger. " 05/01/2008 - "Increased expression of KLF4 protein and mRNA were found in squamous cell carcinoma cell line studies and fresh skin tissue respectively, using western blotting and semi-quantitative real time polymerase chain reaction (PCR). "
4.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/01/2014 - "Homology models, docking studies and promoter activity of its target gene P21CIP confirmed the lack of function of the mutant KLF4 protein in pediatric T-ALL. " 01/01/2014 - "This mutation was a frameshift mutation resulting in alteration of the Zf3 motif sequence in the mutant KLF4 protein in all pediatric T-ALL samples. "
5.	Neoplasm Metastasis (Metastasis) 09/01/2012 - "Expression of KLF4 protein was decreased or lost in primary HCC samples, in particular, lymph node metastases, compared with normal liver tissues. " 07/01/2012 - "KLF4 protein expression was measured by immunohistochemistry on tissue microarray, which contained primary gastric cancer, corresponding para-cancerous tissue, and paired lymph node metastases. " 08/01/2008 - "Loss of KLF4 protein expression might contribute to assessing prognosis in colorectal cancer with lymph node metastasis." 06/15/2008 - "Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells." 01/01/2006 - "Statistically, loss of KLF4 protein expression was not associated with clinocopathologic parameters, including tumor stage (Bartholomew test, P>0.05), lymph node metastasis, differentiation, tumor location, and tumor size (chi2 test, P>0.05). "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Transcription Factors (Transcription Factor)
3.	PPAR gamma
4.	Keratin-20 (Cytokeratin 20)
5.	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)
6.	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)
7.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
8.	Activating Transcription Factor 3
9.	beta Catenin
10.	STAT4 Transcription Factor

Related Therapies and Procedures

1.	Resuscitation