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NNC 14-0189
structure given in first source
Also Known As:
3-(5-cyclopropyl-1,2,4-oxadiazol-3--yl)-7-fluoro-5-(4-methyl-1-piperazinyl)imidazol(1,5-a)quinazoline
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinazolines: 402
NNC 14-0189: 2
Related Diseases
1.
Seizures (Absence Seizure)
11/01/1996 - "
In one approach, mice were chronically treated with either NNC 14-0185 or NNC 14-0189 for 4 weeks at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole.
"
07/11/1996 - "
The anticonvulsant effects of NNC 14-0185 and NNC 14-0189 against pentylenetetrazole-induced seizures were apparent within 5 min of i.p.
"
07/11/1996 - "
NNC 14-0185 and NNC 14-0189 prevented seizures induced by pentylenetetrazole in rats and were also effective anticonvulsants in amygdala-kindled rats.
"
07/11/1996 - "
administration, NNC 14-0185 and NNC 14-0189 prevented audiogenic seizures in DBA/2 mice and the clonic convulsions induced in mice by pentylenetetrazole, DMCM (methyl 6, 7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate), 3-mercaptopropionic acid and a low dose of bicuculline.
"
Related Drugs and Biologics
1.
Pentylenetetrazole (Metrazol)
2.
NNC 14-0185
3.
3-Mercaptopropionic Acid (3 Mercaptopropionic Acid)
4.
Bicuculline
5.
Anticonvulsants (Antiepileptic Drugs)
6.
methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate