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hematopoietic progenitor kinase 1

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functional activator of the JNK/SAPK signaling pathway

Also Known As:

HPK1 (kinase); Hpk1 protein, mouse; MAP4K1 protein, human; Map4k1 protein, mouse; hematopoietic progenitor kinase 1, mouse; hematopoietic progenitor kinase, human; human HPK1; mitogen activated protein kinase kinase kinase kinase 1, mouse; mitogen-activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1, human

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Phosphotransferases: 30637
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9706
        Protein-Serine-Threonine Kinases: 1353
        hematopoietic progenitor kinase 1: 8

Experts

1.	Sawasdikosol, Sansana: 2 articles (12/2012 - 03/2010)
2.	Burakoff, Steven: 2 articles (12/2012 - 03/2010)
3.	Tan, Tse-Hua: 2 articles (02/2009 - 02/2006)
4.	Simon, Scott I: 1 article (05/2013)
5.	Zha, Renyuan: 1 article (12/2012)
6.	Yang, Boyu: 1 article (12/2012)
7.	Liao, Jieyue: 1 article (11/2011)
8.	Liang, Gongping: 1 article (11/2011)
9.	Zhang, Peng: 1 article (11/2011)
10.	Long, Hai: 1 article (11/2011)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2012 - "It is probable that blocking the HPK1 kinase activity with a small molecule inhibitor may activate the superior anti-tumor activity of both cell types, resulting in a synergistic amplification of anti-tumor potential. " 03/01/2010 - "Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response."
2.	Pancreatic Neoplasms (Pancreatic Cancer) 02/01/2009 - "Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer."
3.	Extramammary Paget Disease (Paget Disease, Extramammary) 10/01/2011 - "Hematopoietic progenitor kinase 1, mitogen-activated protein/extracellular signal-related protein kinase kinase kinase 1, and phosphomitogen-activated protein kinase kinase 4 are overexpressed in extramammary Paget disease."
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/01/2011 - "Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus."
5.	Inflammation 05/16/2013 - "In this issue of Blood, Jakob et al report that hematopoietic progenitor kinase 1 (HPK1) participates during signaling of neutrophil recruitment by acting as a regulator of the adhesiveness of the b2-integrin lymphocyte function-associated antigen 1 (LFA-1) during acute inflammation."

Related Drugs and Biologics

1.	Protein Kinases (Protein Kinase)
2.	Phosphotransferases (Kinase)
3.	Proteasome Endopeptidase Complex (Proteasome)
4.	Complementary DNA (cDNA)
5.	Antigens
6.	Amino Acids
7.	GCK-like kinase