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fatty-acid amide hydrolase (fatty acid amide hydrolase)

Subscribe to New Research on fatty-acid amide hydrolase

degrades neuromodulatory fatty-acid amides including anandamide; inhibited by NSAIDS

Also Known As:

fatty acid amide hydrolase; FAAH protein, human; Fa2h protein, mouse; Faah protein, mouse; Faah protein, rat; fatty acid amide hydrolase, human; fatty acid amide hydrolase, mouse; fatty acid amide hydrolase, rat; oleamide hydrolase

Networked: 198 relevant articles (7 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Amidohydrolases: 12
      - fatty-acid amide hydrolase: 198

Experts

1.	Cravatt, Benjamin F: 19 articles (11/2015 - 05/2003)
2.	Fowler, Christopher J: 11 articles (01/2015 - 03/2003)
3.	Maccarrone, Mauro: 11 articles (01/2015 - 05/2003)
4.	Di Marzo, Vincenzo: 10 articles (05/2015 - 08/2002)
5.	Lichtman, Aron H: 10 articles (09/2014 - 05/2003)
6.	Piomelli, Daniele: 8 articles (07/2015 - 09/2005)
7.	Kinsey, Steven G: 6 articles (09/2014 - 03/2009)
8.	de Luis, D A: 6 articles (12/2013 - 03/2010)
9.	Bari, Monica: 6 articles (03/2013 - 05/2003)
10.	Hillard, Cecilia J: 5 articles (11/2015 - 12/2003)

Related Diseases

1.	Pain (Aches) 08/01/2015 - "Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy." 03/01/2014 - "Fatty acid amide hydrolase inhibitors show promise as a treatment for anxiety, depression and pain. " 02/14/2014 - "Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract." 01/01/2014 - "A systems pharmacology perspective on the clinical development of Fatty Acid amide hydrolase inhibitors for pain." 10/01/2012 - "The synonymous rs324419 SNP of the FAAH gene which encodes fatty acid amide hydrolase, a cannabinoid metabolizing enzyme, was associated with PD-related pain (p = 0.006) and specifically with the musculoskeletal subtype. "
2.	Inflammation 10/01/2014 - "The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury." 10/13/2011 - "Here, we focus on the covalent inhibition of the fatty acid amide hydrolase (FAAH), which is a promising strategy in the treatment of pain and inflammation. " 10/01/2011 - "• To determine (i) the presence of fatty acid amide hydrolase (FAAH) in the urinary bladder; (ii) whether or not endogenous fatty acid ethanolamides are synthesized by the bladder; (iii) the effects of FAAH inhibition on referred hyperalgesia associated with acute bladder inflammation in rats. " 10/01/2011 - "Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation." 03/01/2009 - "Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation."
3.	Hyperalgesia 04/01/2012 - "The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice." 05/01/2006 - "1 The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical allodynia in the spinal nerve ligation (SNL) and mild thermal injury (MTI) models in the rat. " 10/01/2011 - "Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice." 10/01/2011 - "• To determine (i) the presence of fatty acid amide hydrolase (FAAH) in the urinary bladder; (ii) whether or not endogenous fatty acid ethanolamides are synthesized by the bladder; (iii) the effects of FAAH inhibition on referred hyperalgesia associated with acute bladder inflammation in rats. " 10/01/2011 - "Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation."
4.	Stroke (Strokes) 03/01/2004 - "NAE accumulation during acute stroke may be due to increased synthesis as well as decreased degradation, possibly by inhibition of fatty acid amide hydrolase (FAAH)." 04/10/2010 - "This review posits that fatty acid amide hydrolase (FAAH) inhibition has therapeutic potential against neuropathological states including traumatic brain injury; Alzheimer's, Huntington's, and Parkinson's diseases; and stroke. " 11/01/2012 - "In vivo restoration of cannabinoid levels, either by administration of the type 1 cannabinoid receptor agonist HU210 or the inhibitor of the principal catabolic enzyme fatty acid amide hydrolase, URB597, completely reverted the increased morbidity and mortality of adult neural stem and progenitor cell-ablated mice suffering from epilepsy and ischaemic stroke. "
5.	Headache (Headaches) 10/01/2012 - "A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication-overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication-overuse headache subjects before withdrawal treatment. " 08/01/2015 - "Thus, patients suffering from chronic migraine or medication overuse headache showed alterations in the activity of the arachidonoylethanolamide (AEA) degrading enzyme fatty acid amide hydrolase (FAAH) and a specific AEA membrane transporter, alongside with changes in AEA levels. " 10/01/2012 - "We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication-overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls. "

Related Drugs and Biologics

1.	anandamide (arachidonylethanolamide)
2.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester (URB597)
3.	Endocannabinoids (Endocannabinoid)
4.	Cannabinoid Receptors (Cannabinoid Receptor)
5.	Lipase (Acid Lipase)
6.	Serotonin (5 Hydroxytryptamine)
7.	Glycerol (Glycerine)
8.	HU 211 (HU 210)
9.	piperazine
10.	JZL 184

Related Therapies and Procedures

1.	Analgesia
2.	Therapeutics
3.	Biliopancreatic Diversion
4.	Ligation
5.	Drug Therapy (Chemotherapy)