cyclohexenoesculetin-beta-galactoside (S-Gal)

05/01/2013 - "The study demonstrates that the response of neutrophils from patients with COPD to VGVAPG varied according to COPD phase and critical level of S-Gal expression. "
05/01/2013 - "These findings were associated with a decreased or almost complete loss of S-Gal elastin receptor expression in neutrophils from patients with stable or exacerbated COPD, respectively. "
01/13/2021 - "Monitoring IL-4 in circulating CD4+ T-cells may help to better characterize COPD phenotypes and could open a new pharmacologic opportunity through CD4+ T-cells stimulation via the VGVAPG/S-gal receptor in order to favor an anti-inflammatory response in those COPD patients."

07/01/2005 - "We propose that S-Gal might constitute a novel therapeutic target for controlling melanoma progression."
02/01/2004 - "Upregulation of MMP-2 activation by ED led to enhanced melanoma cells invasion through S-Gal occupancy. "
02/01/2004 - "Immunohistochemistry studies, confirmed that S-Gal expression was more prominent at the melanoma invasion site associated with a strong expression of MMP-2 and MT1-MMP. "
02/01/2004 - "We hypothesize that ED following interactions with S-Gal elastin receptor can favor melanoma cells invasion through a three-dimensional type I collagen matrix by upregulating MMP-2 activation."
02/01/2004 - "The effects of ED on melanoma cells were found to be mediated by splicing form of beta-galactosidase (S-Gal) occupancy, as being suppressed by lactose. "

09/01/2017 - "In this study, we investigated the S-gal-dependent EP effects on T-helper (Th) and T-cytotoxic (Tc) responses during murine EP-triggered pulmonary inflammation. "

07/01/2000 - "The present study provides a novel and natural model validating functional roles of S-Gal in elastogenesis and elucidates an association between impaired elastogenesis and the development of connective-tissue disorders in patients with Morquio B disease and in patients with an infantile form of GM1-gangliosidosis."

09/01/2017 - "This study demonstrates that, during murine emphysema, EP-S-gal interactions contribute to a Th-1 and Th-17 proinflammatory T-cell response combined with a Tc-1 response. "
09/01/2017 - "Elastin receptor (S-gal) occupancy by elastin peptides modulates T-cell response during murine emphysema."