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2-(2-imidazolin-2-yl)-1-phenyl-1H-indole

an imidazoline compound; structure given in first source

Also Known As:

RX 871024; RX-871024; RX871024

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 2-(2-imidazolin-2-yl)-1-phenyl-1H-indole: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 2-(2-imidazolin-2-yl)-1-phenyl-1H-indole: 3

Experts

1.	Berggren, Per-Olof: 1 article (01/2016)
2.	Zaitsev, Sergei V: 1 article (01/2016)
3.	Zaitseva, Irina I: 1 article (01/2016)
4.	Appelskog, I B: 1 article (02/2001)
5.	Berggren, P O: 1 article (02/2001)
6.	Efendic, S: 1 article (02/2001)
7.	Kapelioukh, I L: 1 article (02/2001)
8.	Köhler, M: 1 article (02/2001)
9.	Yang, S N: 1 article (02/2001)
10.	Zaitsev, S V: 1 article (02/2001)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 02/01/2001 - "One of the major findings in this study is that imidazoline compounds RX871024 and efaroxan, suggested as prototypes of a new generation of drugs against type 2 diabetes, can protect against IL-1beta-induced apoptosis in pancreatic beta-cells, possibly by their inhibition of the expression of iNOS, a key element in the IL-1beta-induced apoptotic pathway in pancreatic beta-cells. "
2.	Starvation 07/01/1999 - "In freshly isolated islets, the effects of RX871024 on insulin secretion could be converted from inhibitory to stimulatory, by starvation of the animals. "
3.	Insulinoma 01/01/2016 - "The specific cytotoxic effect of imidazoline compound RX871024 on insulinoma cell death but not primary β-cell death is independent of its action on AMPK and may suggest the possibility of using this type of compound in the treatment of insulinomas." 01/01/2016 - "RX871024 aggravated AICAR-induced insulinoma MIN6 cell death regardless of the presence of pro-inflammatory cytokines. " 01/01/2016 - "The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition." 01/01/2016 - "We have previously shown that the insulinotropic imidazoline compound RX871024 induces death of insulinoma MIN6 cells, an effect involving stimulation of c-Jun N-terminal kinase (JNK) and caspase 3. It has also been reported that AMP-activated protein kinase (AMPK) activates JNK and induces β-cell death. "

Related Drugs and Biologics

1.	Imidazolines
2.	Elements
3.	efaroxan
4.	AMP-Activated Protein Kinases
5.	Caspase 3 (Caspase-3)
6.	JNK Mitogen-Activated Protein Kinases
7.	Cytokines
8.	AICA ribonucleotide (ZMP)