vitamin D-binding protein-macrophage activating factor

formed when deglycosylated at O-linked site near C-terminus; incubation of human group-specific component with mixture of beta-galactosidase and sialidase generates macrophage activating factor, GcMAF

Also Known As:

Networked: 56 relevant articles (7 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Uto, Yoshihiro: 13 articles (11/2020 - 05/2002)
2.	Hori, Hitoshi: 9 articles (08/2014 - 05/2002)
3.	Morucci, Gabriele: 7 articles (02/2015 - 04/2011)
4.	Pacini, Stefania: 7 articles (02/2015 - 04/2011)
5.	Inui, Toshio: 6 articles (07/2016 - 07/2013)
6.	Kubo, Kentaro: 6 articles (07/2016 - 07/2013)
7.	Kuchiike, Daisuke: 6 articles (07/2016 - 07/2013)
8.	Gulisano, Massimo: 6 articles (02/2015 - 04/2011)
9.	Ruggiero, Marco: 6 articles (02/2015 - 04/2011)
10.	Yamamoto, Nobuto: 6 articles (07/2011 - 09/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "These results are consistent with the hypothesis that the known anticancer efficacy of DBP-MAF can be ascribed to different biological properties of the molecule that include inhibition of tumour-induced angiogenesis and direct inhibition of cancer cell proliferation, migration and metastatic potential." 07/01/2016 - "Clinical trials of second-generation GcMAF demonstrated remarkable clinical effects in several types of cancers. " 10/18/2010 - "These studies show strong inhibitory activity of DBP-maf on prostate tumor cells independent of its macrophage activation." 10/18/2010 - "In this study we show for the first time that DBP-maf exhibits a direct and potent effect on prostate tumor cells in the absence of macrophages. " 07/22/2022 - "It is shown that macrophage activation by GcMAF-RF is inhibited by tumor-secreted factors. "
2.	Breast Neoplasms (Breast Cancer) 01/15/2008 - "Efficacy of GcMAF for treatment of metastatic breast cancer was investigated with 16 nonanemic patients who received weekly administration of GcMAF (100 ng). " 07/08/2013 - "In this study we demonstrate that GcMAF stimulates macrophages, which in turn attack human breast cancer cells, induce their apoptosis and eventually phagocytize them. " 01/01/2012 - "Effects of vitamin D-binding protein-derived macrophage-activating factor on human breast cancer cells." 01/01/2012 - "DBP-MAF inhibited human breast cancer cell proliferation and cancer cell-stimulated angiogenesis. " 07/08/2013 - "A novel role for a major component of the vitamin D axis: vitamin D binding protein-derived macrophage activating factor induces human breast cancer cell apoptosis through stimulation of macrophages."
3.	Inflammation (Inflammations) 09/01/2003 - "Our studies indicate that, during inflammation DBP-maf may function positively by causing death of the macrophages when activated macrophages are no longer needed at the site of inflammation. " 01/01/1999 - "The cure with subthreshold GcMAF-treatments (administered once or twice) of tumor-bearing mice appeared to be a consequence of sustained macrophage activation by inflammation resulting from the macrophage-mediated tumoricidal process. " 11/01/2002 - "Gc protein has been reported to be a precursor of Gc protein-derived macrophage activation factor (GcMAF) in the inflammation-primed macrophage activation cascade. " 09/01/2004 - "Serum vitamin D-binding protein (Gc protein or DBP) is a highly expressed polymorphic protein, which is a precursor of the inflammation-primed macrophage activating factor, GcMAF, by a cascade of carbohydrate processing reactions. " 09/01/2003 - "Vitamin D-binding protein-macrophage-activating factor (DBP-maf) is derived from serum vitamin D binding protein (DBP) by selective deglycosylation during inflammation. "
4.	Ascites 06/01/1998 - "Although malignant tumours are poorly immunogenic, 4 days after GcMAF-primed immunization of mice with heat-killed Ehrlich ascites tumour cells, the ascites tumour was no longer transplantable in these mice." 01/01/1999 - "Therefore, a protracted macrophage activation induced by a few administrations of minute amounts of GcMAF eradicated the murine ascites tumor." 07/01/2013 - "We also found that GcMAF-containing human serum significantly enhanced the phagocytic activity of mouse peritoneal macrophages and extended the survival time of mice bearing Ehrlich ascites tumors. "
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/01/2017 - "We recommend a prospective randomized double blind study to assess the sustained efficacy of MSC and GcMAF in the treatment of autoimmune connective tissue diseases such as systemic lupus erythematosus." 03/01/1997 - "When peripheral blood monocytes/ macrophages (designated macrophages) of 33 systemic lupus erythematosus patients were incubated with GcMAF (100 pg/ml), the macrophages of all patients were activated as determined by superoxide generation. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Neuraminidase (Sialidase)
3.	Galactosidases
4.	Cholecalciferol (Vitamin D3)
5.	Thioctic Acid (Lipoic Acid)
6.	Ascorbic Acid (Vitamin C)
7.	vitamin D-binding protein-macrophage activating factor
8.	Vitamin D-Binding Protein
9.	alpha-N-Acetylgalactosaminidase (N-Acetyl-alpha-D-Galactosaminidase)
10.	Angiogenesis Inducing Agents (Angiogenesis Factor)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Transplantation
4.	Injections
5.	Drug Therapy (Chemotherapy)