sclerotiorin

isolated from monoverticillate Penicillia; RN given for (R-(R*,S*-(E,E)))-isomer; structure in first source

Also Known As:

sclerotiorin, (S-(R*,R*-(E,E)))-isomer; 6H-2-Benzopyran-6,8(7H)-dione, 7-(acetyloxy)-5-chloro-3-((1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl)-7-methyl-, (7R)-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - sclerotiorin: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - sclerotiorin: 4

Experts

1.	Chen, Guang-Ying: 1 article (03/2022)
2.	Geng, Jia-Jia: 1 article (03/2022)
3.	Gu, Yu-Cheng: 1 article (03/2022)
4.	Hai, Yang: 1 article (03/2022)
5.	Hou, Xue-Mei: 1 article (03/2022)
6.	Li, Peng-Jie: 1 article (03/2022)
7.	Liu, Ming: 1 article (03/2022)
8.	Ma, Wei-Ping: 1 article (03/2022)
9.	Shao, Chang-Lun: 1 article (03/2022)
10.	Wang, Cui-Fang: 1 article (03/2022)

Related Diseases

1.	Neoplasms (Cancer) 03/15/2022 - "Herein, a series of semisynthesized derivatives (2-30) of the natural product (+)-sclerotiorin (1) was prepared and evaluated the cytotoxic activities against six cancer cell lines. " 07/01/2012 - "Sclerotiorin was found to be potent anti-proliferative against different cancer cells. " 07/01/2012 - "In this study sclerotiorin has been found to induce apoptosis in colon cancer (HCT-116) cells through the activation of BAX, and down-regulation of BCL-2, those further activated cleaved caspase-3 causing apoptosis of cancer cells."
2.	Colonic Neoplasms (Colon Cancer) 07/01/2012 - "In this study sclerotiorin has been found to induce apoptosis in colon cancer (HCT-116) cells through the activation of BAX, and down-regulation of BCL-2, those further activated cleaved caspase-3 causing apoptosis of cancer cells."
3.	Breast Neoplasms (Breast Cancer) 12/29/2020 - "A series of sclerotiorin derivatives have been synthesized and screened for their cytotoxic activity against human lung cancer cells A549, breast cancer cells MDA-MB-435 using the MTT method. " 01/01/2015 - "However, sclerotiorin showed no cytotoxic effect on breast cancer Hs578T, MDA-MB-231 and prostate cancer LNCaP cell lines. "
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2015 - "However, sclerotiorin showed no cytotoxic effect on breast cancer Hs578T, MDA-MB-231 and prostate cancer LNCaP cell lines. "
5.	Lung Neoplasms (Lung Cancer) 12/29/2020 - "A series of sclerotiorin derivatives have been synthesized and screened for their cytotoxic activity against human lung cancer cells A549, breast cancer cells MDA-MB-435 using the MTT method. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Antineoplastic Agents (Antineoplastics)