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sildenafil (Viagra)

A 7,8-pyrazolo-pyrimidine, differing from PURINES which are 7,9-pyrazolo-pyrimidines; Viagra (tradename) is sildenafil citrate, used in oral therapy for male erectile dysfunction

Also Known As:

Viagra; sildenafil citrate; 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate; Abbott brand of sildenafil citrate; Pfizer brand 1 of sildenafil citrate; Pfizer brand 2 of sildenafil citrate; Revatio; UK 92480-10; UK-92,480-10; acetildenafil; desmethyl sildenafil; desmethylsildenafil; homosildenafil; hydroxyhomosildenafil

Networked: 2747 relevant articles (501 outcomes, 575 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kukreja, Rakesh C: 23 articles (03/2015 - 09/2002)
2.	Grimminger, Friedrich: 18 articles (06/2015 - 04/2002)
3.	Mulhall, John P: 16 articles (09/2014 - 01/2004)
4.	Das, Anindita: 15 articles (03/2015 - 02/2004)
5.	Tanus-Santos, Jose E: 14 articles (12/2015 - 09/2004)
6.	Seeger, Werner: 14 articles (06/2015 - 04/2002)
7.	Guazzi, Marco: 14 articles (07/2013 - 10/2004)
8.	Montorsi, Francesco: 14 articles (05/2012 - 09/2002)
9.	Kass, David A: 13 articles (10/2014 - 01/2005)
10.	Althof, Stanley E: 13 articles (04/2014 - 05/2003)

Related Diseases

1.	Erectile Dysfunction 03/01/2006 - "A combined approach of sildenafil and sex therapy proved highly effective in treatment of honeymoon impotence of psychogenic origin; however, controlled studies are needed. " 08/01/2005 - "Sildenafil, a highly selective inhibitor of PDE 5, is effective in the treatment of erectile dysfunction. " 07/01/2005 - "Most of the available data on efficacy for sildenafil are based on a questionnaire and erectile dysfunction (ED) is classified with minor or severe organic factors. " 04/01/2004 - "Sildenafil, a highly selective inhibitor of phosphodiesterase type 5, is effective in the treatment of erectile dysfunction. " 12/20/2000 - "In most patients with good sleep efficiency and who have erectile dysfunction, sildenafil, rather than a placebo, taken at bedtime produces a significantly improved nocturnal erectile activity. "
2.	Pulmonary Hypertension (Ayerza Syndrome) 07/01/2014 - "Intravenous sildenafil treatment has recently shown promising results and good tolerability in the treatment of refractory pulmonary hypertension (PH) in term and near-term neonates, while comparable data in preterm infants are still lacking. " 04/01/2012 - "Alternate therapies such as sildenafil may be beneficial in this specific population as well as in other causes of pulmonary hypertension. " 01/01/2006 - "Sildenafil has beneficial effects on cerebral vascular reactivity indicative of an improvement in neurovascular coupling in patients with pulmonary hypertension. " 08/01/2009 - "Long-term use of sildenafil in patients with secondary forms of pulmonary hypertension is associated with a sustained improvement in cardio-pulmonary haemodynamics. " 05/01/2014 - "It is concluded that sildenafil is effective in reducing pulmonary hypertension when administered preoperatively in patients with severe pulmonary hypertension undergoing mitral valve replacement surgery."
3.	Heart Failure 11/01/2014 - "Fourteen patients were included, 8 patients in group 1 and 6 in group 2. Sildenafil was administered with a mean dose of 56.2 ± 9.4 mg in group 1 and was able to significantly reduce right heart failure incidence, and to demonstrate a significant reduction in pulmonary vascular resistance, pulmonary artery pressure, transpulmonary gradient, and a significant increase in cardiac output. " 03/01/2011 - "In light of its documented protective effects at the myocardial level in heart failure, sildenafil presents a particularly attractive strategy in that it simultaneously targets cardiac remodeling and secondary PH-LHD." 12/01/2004 - "Oral sildenafil is safe and effective for the evaluation of PH reactivity in heart failure." 09/01/2004 - "Sildenafil was safe and improved erectile function and quality of life in men with moderately severe congestive heart failure." 01/01/2014 - "One-year sildenafil therapy effectively improved clinical status and pulmonary vascular resistance in patients diagnosed with congestive heart failure."
4.	Hypertension (High Blood Pressure) 01/01/2011 - "It is concluded that sildenafil was a well-tolerated and highly effective treatment of ED in outpatients with diabetes and/or hypertension from the three Middle Eastern countries studied." 06/01/2005 - "Clinical studies have demonstrated that sildenafil successfully treats ED of varied organic, psychogenic or mixed aetiology, and is effective in men with ED and comorbidities such as hypertension, hyperlipidaemia, diabetes or depression. " 03/01/2009 - "To date, PDE5 inhibition has been shown to be effective for the treatment of idiopathic pulmonary artery hypertension, and sildenafil is approved for this indication. " 01/01/2009 - "The objective of this study was to determine the hemodynamic outcome in a consecutive cohort of patients offered sildenafil as first-line treatment for portopulmonary hypertension. " 04/01/2006 - "A randomized, placebo-controlled, double-blind, crossover study to evaluate the efficacy of oral sildenafil therapy in severe pulmonary artery hypertension."
5.	Prostatic Neoplasms (Prostate Cancer) 01/01/2005 - "Subsequently, sildenafil has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED. " 12/01/2001 - "Sildenafil is well tolerated and effective in improving erectile function of patients with ED after 3D-CRT for prostate cancer." 04/01/2001 - "In men receiving 3DCRT for prostate cancer, these data indicate that sildenafil citrate is effective for restoring SF and associated satisfaction back to baseline before treatment." 10/19/2010 - "In the present study, we further investigated the potential effects of sildenafil on improving antitumor efficacy of DOX in prostate cancer. " 07/01/2005 - "The efficacy of sildenafil citrate following radiation therapy for prostate cancer: temporal considerations."

Related Drugs and Biologics

1.	sildenafil (Viagra)
2.	Type 5 Cyclic Nucleotide Phosphodiesterases
3.	tadalafil (Cialis)
4.	vardenafil (Levitra)
5.	Phosphodiesterase 5 Inhibitors
6.	bosentan (Tracleer)
7.	Idiopathic pulmonary hypertension
8.	Testosterone (Sustanon)
9.	Alprostadil (Muse)
10.	Endothelin Receptors (Endothelin Receptor)

Related Therapies and Procedures

1.	Prostatectomy (Retropubic Prostatectomy)
2.	Brachytherapy
3.	Radiotherapy
4.	Transplantation (Transplant Recipients)
5.	Renal Dialysis (Hemodialysis)