posaconazole

Also Known As:

4-(p-(4-(p-(((3R,5R)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furyl)methoxy)phenyl)-1-piperazinyl)phenyl)-1-((1S,2S)-1-ethyl-2-hydroxypropyl)-delta(sup 2)-1,2,4-triazolin-5-one; Noxafil; SCH 56592; SCH-56592; posaconazole hydrate

Networked: 1189 relevant articles (201 outcomes, 180 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - posaconazole: 1189

Experts

1.	Cornely, Oliver A: 33 articles (10/2021 - 01/2006)
2.	Guarro, Josep: 31 articles (06/2017 - 10/2008)
3.	Kontoyiannis, Dimitrios P: 20 articles (11/2021 - 12/2005)
4.	Verweij, Paul E: 18 articles (07/2022 - 11/2003)
5.	Pastor, F Javier: 17 articles (10/2012 - 10/2008)
6.	Graybill, John R: 16 articles (03/2010 - 05/2002)
7.	Waskin, Hetty: 15 articles (08/2022 - 07/2014)
8.	Ullmann, Andrew J: 15 articles (12/2017 - 06/2006)
9.	Brüggemann, Roger J M: 14 articles (07/2022 - 05/2009)
10.	Walsh, Thomas J: 14 articles (01/2021 - 01/2004)

Related Diseases

1.	Infections 05/01/2014 - "Adequate penetration to the infection/colonization site is crucial to attain optimal efficacy of posaconazole against Aspergillus fumigatus diseases. " 04/01/2019 - "We report a patient post cardiac transplant who had pulmonary infection with V gallopava and was treated successfully with posaconazole." 06/01/2007 - "Posaconazole appears to be an effective alternative in the management of MC in these difficult-to-treat infections." 01/01/2021 - "Efficacy of Posaconazole against Rhizopus oryzae Infection in Silkworm." 12/01/2015 - "We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. "
2.	Invasive Fungal Infections 01/01/2018 - "Posaconazole was ranked highest in effectiveness for primary prophylaxis, being the most favorable in terms of (i) the RR for reduction of invasive fungal infection (0.19; 95% confidence interval [CI], 0.11 to 0.36) and (ii) the probability of being the best option (94% of the cumulative ranking). " 12/01/2011 - "Posaconazole prophylaxis has proven highly effective in preventing invasive fungal infections, despite relatively low serum concentrations. " 01/01/2006 - "A large number of experimental animal models of invasive fungal infections has demonstrated the potent and broad-spectrum efficacy of posaconazole in vivo, both in normal and in immunocompromised animals. " 02/01/2015 - "Due to sustained, higher drug concentrations, the new posaconazole formulations hold promise for greater efficacy in antifungal prophylaxis and bring opportunity for further study in the treatment of invasive mycoses. " 01/01/2022 - "Prophylaxis with posaconazole (PP) is effective in the prevention of invasive fungal infections in immunocompromised adult patients. "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2020 - "Our objective was to determine the efficacy of antifungal prophylaxis by posaconazole on IA incidence in acute myeloid leukemia population and to analyse the benefit of this prophylaxis and HEPA-filters during hospital buildings works. " 11/13/2018 - "The Outcome of Antifungal Prophylaxis with Posaconazole in Patients with Acute Myeloid Leukemia: A Single-Center Study" 04/01/2018 - "A cost-effectiveness simulation was conducted on the basis of a pivotal study on the use of posaconazole in acute myeloid leukemia (AML) patients, adjusting the costs to Brazilian data. " 05/15/2023 - "Isavuconazonium or posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia." 01/01/2020 - "In the past, patients at high risk of invasive mucomycosis (IM) were those affected by acute myeloid leukemia but over the last ten years the prophylaxis with a very effective mold-active drug, such as posaconazole, has completely modified the epidemiology. "
4.	Mycoses (Diseases, Fungus) 02/01/2014 - "Prior clinical trials have demonstrated efficacy and effectiveness of posaconazole in the prophylaxis of invasive fungal diseases in high-risk patients. " 11/01/2013 - "Our data suggest that posaconazole was effective in reducing the rate and probability of invasive fungal disease in high-risk patients." 01/01/2008 - "Posaconazole prophylaxis during periods of high risk was recently demonstrated to be effective in preventing fungal infections and associated mortality. " 02/14/2018 - "Conclusion: Posaconazole is safe and effective for primary prevention of fungal infection of SAA patients receiving IST, especially for the VSAA. " 01/01/2018 - "Expert Commentary: Posaconazole has proved safe and effective in preventing and treating fungal infections in immunocompromised children. "
5.	Aspergillosis 10/01/2020 - "Posaconazole treatment was associated with a significant reduction in IFIs (RR, 0.57; 95% CI, 0.42-0.79) and invasive aspergillosis (RR, 0.36; 95% CI, 0.15-0.85) compared with placebo. " 01/01/2016 - "The aim of this study was to determine the safety and efficacy of posaconazole for the treatment of naturally occurring disseminated Aspergillus infections in dogs. " 02/01/2010 - "The in vivo efficacy of posaconazole against 4 clinical Aspergillus fumigatus isolates with posaconazole MICs ranging from 0.03 to 16 mg/liter, as determined by CLSI method M38A, was assessed in a nonneutropenic murine model of disseminated aspergillosis. " 10/01/2004 - "We compared posaconazole with other antifungals for efficacy against murine CNS aspergillosis. " 10/01/2004 - "Efficacy of posaconazole in a murine model of central nervous system aspergillosis."

Related Drugs and Biologics

1.	Amphotericin B (Amphotericin)
2.	Voriconazole (Vfend)
3.	Itraconazole (Sporanox)
4.	liposomal amphotericin B
5.	Fluconazole (Zonal)
6.	Triazoles
7.	Terbinafine (Lamisil)
8.	benzonidazole (benznidazole)
9.	Azoles
10.	Caspofungin (Cancidas)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Salvage Therapy
4.	Debridement
5.	Induction Chemotherapy