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9- (2- methylidene- 3- (phosphonomethoxy)propyl)guanine
has anti-HIV activity; acyclonucleotide analog of cGMP;structure given in first source
Also Known As:
MDL 74,968; MDL 74968; MDL-74968
Networked:
2
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purinones: 2
Hypoxanthines: 1
Guanine: 1793
9-(2-methylidene-3-(phosphonomethoxy)propyl)guanine: 2
Related Diseases
1.
HIV Infections (HIV Infection)
05/01/1996 - "
Taken together, these promising findings suggest that an orally bioavailable prodrug of MDL 74,968 should be developed for the treatment of HIV infection.
"
05/01/1996 - "
Treatment by continuous subcutaneous infusion of MDL 74,968 or PMEA at the daily dose of 20 mg/kg in the hu-PBL-SCID.beige murine model of HIV infection significantly reduced the severity of infection compared with that in placebo-treated controls.
"
2.
Infections
05/01/1996 - "
MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection.
"
05/01/1996 - "
Treatment by continuous subcutaneous infusion of MDL 74,968 or PMEA at the daily dose of 20 mg/kg in the hu-PBL-SCID.beige murine model of HIV infection significantly reduced the severity of infection compared with that in placebo-treated controls.
"
3.
Body Weight (Weight, Body)
05/01/1996 - "
Studies of acute toxicity in CD-1 mice showed that MDL 74,968 was not toxic at doses of 1,600 mg/kg of body weight via the intraperitoneal route or at doses of 500 mg/kg via the intravenous route.
"
03/01/1997 - "
PMEA, (R)-PMPA, and MDL 74,968 afforded a marked delay in MSV-induced tumor initiation in MSV-infected newborn NMRI mice and substantially delayed associated animal death at doses as low as 4 to 10 mg/kg of body weight.
"
4.
Sarcoma (Soft Tissue Sarcoma)
03/01/1997 - "
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice.
"
5.
Neoplasms (Cancer)
03/01/1997 - "
PMEA, (R)-PMPA, and MDL 74,968 afforded a marked delay in MSV-induced tumor initiation in MSV-infected newborn NMRI mice and substantially delayed associated animal death at doses as low as 4 to 10 mg/kg of body weight.
"
Related Drugs and Biologics
1.
Organophosphonates (Phosphonates)
2.
Prodrugs
3.
Nucleosides
4.
Adenine
5.
Tenofovir (Viread)
Related Therapies and Procedures
1.
Subcutaneous Infusions