MDL 74,180

Also Known As:

2,3-dihydro-2,2,4,6,7-pentamethyl-3-(4-methylpiperazino)-methyl-1-benzofuran-5-ol; MDL 74180; MDL-74180

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Craniocerebral Trauma (Head Injury) 06/27/1996 - "MDL 74,180 is a potential treatment for the oedema caused as a result of head injury." 06/27/1996 - "In the present study the effects of free radical suppression with MDL 74,180 (2,3-dihydro-2,2,4,6,7-pentamethyl-3-(4-methylpiperazino)-methyl-1 - benzofuran-5-ol dihydrochloride), an alpha-tocopherol analogue free radical scavenger, on the development of cerebral oedema resulting from head injury has been assessed. "
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 03/18/1996 - "Tissue damage following middle cerebral artery occlusion (2 h) and reperfusion (8 days) was decreased by MDL 74,180 (0.1 and 1.0 mg/kg per h) infusion beginning 15 min before the onset of reperfusion and continuing for 2 h into the reperfusion period, in a dose-related manner. "
3.	Cerebral Infarction 03/18/1996 - "MDL 74,180 reduces cerebral infarction and free radical concentrations in rats subjected to ischaemia and reperfusion."