prostate apoptosis response-4 protein

induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C; do not confuse with protease-activated receptor 4; RefSeq NM_002583 (human); XM_125814 (mouse); NM_033485 (rat)

Also Known As:

PAWR protein, human; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator protein rat; PRKC, apoptosis, WT1, regulator protein, human; PRKC, apoptosis, WT1, regulator protein, mouse; Par-4 (prostate apoptosis) protein, rat; Par-4 protein, human; Pawr protein, mouse; Pawr protein, rat; prostate apoptosis response-4 protein, human; prostate apoptosis response-4 protein, mouse; prostate apoptosis response-4 protein, rat

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - prostate apoptosis response-4 protein: 7
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - prostate apoptosis response-4 protein: 7

Experts

1.	Burikhanov, Ravshan: 3 articles (01/2017 - 06/2015)
2.	Rangnekar, Vivek M: 3 articles (01/2017 - 06/2015)
3.	Liu, Chunming: 2 articles (01/2016 - 06/2015)
4.	Sviripa, Vitaliy M: 2 articles (01/2016 - 06/2015)
5.	Watt, David S: 2 articles (01/2016 - 06/2015)
6.	Fang, Yi: 1 article (03/2018)
7.	Gao, Jidong: 1 article (03/2018)
8.	Han, Hui: 1 article (03/2018)
9.	Wang, Jing: 1 article (03/2018)
10.	Zou, Mingjin: 1 article (03/2018)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 06/03/2015 - "This inhibition promoted the secretion of Prostate Apoptosis Response-4 protein (Par-4), which selectively triggered apoptosis in prostate cancer cells such as CWR22Rv1, LNCaP-derivative C4-2B, PC-3 and its aggressive analog, PC-3 MM2." 01/07/2016 - "Prostate apoptosis response-4 protein (Par-4) is a tumor suppressor that causes apoptosis in therapy-resistant prostate cancer cells by binding specifically to a receptor, Glucose-regulated protein-78 (GRP78), found only on the surface of cancer cells. "
2.	Neoplasms (Cancer) 01/01/2017 - "A Naturally Generated Decoy of the Prostate Apoptosis Response-4 Protein Overcomes Therapy Resistance in Tumors." 01/07/2016 - "Prostate apoptosis response-4 protein (Par-4) is a tumor suppressor that causes apoptosis in therapy-resistant prostate cancer cells by binding specifically to a receptor, Glucose-regulated protein-78 (GRP78), found only on the surface of cancer cells. "
3.	Denys-Drash Syndrome 03/01/1999 - "We show that two WT1-interacting proteins, the product of a Denys-Drash syndrome allele of wt1 and prostate apoptosis response-4 protein, inhibit WT1-mediated transactivation of Dax-1. "
4.	Parkinson Disease (Parkinson's Disease) 01/01/2004 - "Absence of prostate apoptosis response-4 protein in substantia nigra of Parkinson's disease autopsies."
5.	Melanoma (Melanoma, Malignant) 03/01/2018 - "The perturbed phosphoproteins were: Cleavage and polyadenylation specificity factor subunit 7, elongation factor 2 (EEF2), HIRA-interacting protein 3, melanoma-associated antigen D2, myosin phosphatase Rho-interacting protein, probable E3 ubiquitin-protein ligase MYCBP2, PRKC apoptosis WT1 regulator protein, protein phosphatase 1 regulatory subunit 12A, E3 SUMO-protein ligase RanBP2, Septin-9, thymopoietin, and E3 UFM1-protein ligase 1. Western blotting confirmed that Rg3 increased the phosphorylation of EEF2 on Thr57 but did not alter the protein expression of EEF2 in MDA-MB-231 and HCC1143 cells. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein Phosphatase 1
3.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
4.	Myosin-Light-Chain Phosphatase
5.	Cleavage And Polyadenylation Specificity Factor
6.	SUMO-1 Protein (SUMO Protein)
7.	Peptide Elongation Factor 2 (EF-2)
8.	Thymopoietins (TP 49)
9.	Phosphoproteins
10.	Ligases (Synthetase)

Related Therapies and Procedures

1.	Therapeutics