decursin

activates protein kinase C; isolated from the root of Angelica gigas; RN given for (S)-isomer; structure in first source

Also Known As:

2-butenoic acid, 2-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo(1,2-b:5,4-b')dipyran-7-yl ester, (2Z)-; 2H,6H-benzo(1,2-b:5,4-b')dipyran-2-one, 7,8-dihydro-7-hydroxy-8,8-dimethyl-, (S)-; decursinol; decursinol angelate; 2-butenoic acid, 3-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano(3,2-G)-1-benzopyran-7-yl ester

Networked: 101 relevant articles (15 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Sung-Hoon: 13 articles (03/2016 - 01/2006)
2.	Song, Gyu-Yong: 9 articles (02/2022 - 12/2007)
3.	Jiang, Cheng: 8 articles (01/2021 - 01/2006)
4.	Lü, Junxuan: 7 articles (01/2021 - 01/2009)
5.	Lee, Hyo-Jung: 6 articles (01/2013 - 01/2006)
6.	Zhang, Jinhui: 5 articles (01/2021 - 02/2012)
7.	Xing, Chengguo: 5 articles (01/2017 - 02/2012)
8.	Lee, Jee-Hyun: 4 articles (01/2019 - 12/2007)
9.	Li, Li: 4 articles (02/2018 - 02/2012)
10.	Ahn, Eun-Mi: 4 articles (01/2016 - 01/2004)

Related Diseases

1.	Colitis 01/01/2020 - "Erratum to "Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses" [Biomol. " 01/01/2019 - "Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses."
2.	Neoplasms (Cancer) 01/01/2020 - "Our study emphasizes that decursin may be an effective treatment strategy for various cancers in which LPS and PRP4 perform a critical role in inducing inflammatory response and morphological changes leading to cell survival and protection against anti-cancer drugs." 08/30/2023 - "This study reported a simple and effective method for chiral separation of decursinol and its derivatives, which are pyranocoumarin compounds with anti-cancer and anti-inflammatory properties. " 11/01/2020 - "The aim of this study was to identify whether decursin exhibits anti-cancer activity by targeting HIF-1α. " 12/01/2015 - "Cell culture structure-activity studies have uncovered distinct cellular and molecular effects of D and DA vs. their pyranocoumarin core decursinol (DOH) with respect to cancer cells and those associated with their microenvironment. " 08/01/2014 - "Studies are currently underway to test decursin as a potential therapeutic agent for cancer. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2007 - "These data provide mechanistic rationales for validating the chemopreventive and therapeutic efficacy of decursin and its derivatives in preclinical animal models of breast cancer." 05/01/2014 - "However, the effect of decursin on breast cancer invasion is unknown. " 05/01/2014 - "Decursin prevents TPA-induced invasion through suppression of PKCα/p38/NF-κB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells." 01/01/2007 - "The side chain of decursin and DA is crucial for their anti-ER signaling and breast cancer growth inhibitory activities. " 02/01/2014 - "This study demonstrates that decursin, a bioactive compound from Angelica gigas, exert the anti-cancer effect against breast cancer cells via regulation of Pin1 and its related signaling molecules. "
4.	Sepsis (Septicemia) 04/01/2008 - "These results suggest that decursinol could be effective for prevention or treatment of sepsis." 01/01/2019 - "In the present study, several decursin analogues (KC1-3) were synthesized and evaluated in terms of their anti-septic activities on high mobility group box 1 (HMGB1)-mediated septic responses and survival rate in a mouse model of sepsis. " 04/01/2008 - "The effects of decursinol on various models of sepsis were investigated. " 10/11/2021 - "Decursinol Angelate Mitigates Sepsis Induced by Methicillin-Resistant Staphylococcus aureus Infection by Modulating the Inflammatory Responses of Macrophages." 04/01/2008 - "Protective effect of decursinol on mouse models of sepsis: enhancement of interleukin-10."
5.	Colonic Neoplasms (Colon Cancer) 04/01/2010 - "Thus, these findings suggest that decursin has potential therapeutic efficacy for the treatment of bladder and colon cancer." 04/01/2010 - "In the present study, we found that decursin inhibited cell viability in cultured human urinary bladder cancer 235J cells and colon cancer HCT116 cells. " 04/01/2010 - "Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation." 12/01/2012 - "The in vitro anti-tumor activities of decursin and/or DA against prostate cancer, lung cancer, breast cancer, colon cancer, bladder cancer, sarcoma, myeloma and leukemia have been increasingly reported in the past decade whereas the in vivo efficacy in mouse models was established only for a few organ sites. "

Related Drugs and Biologics

1.	decursin
2.	Dextrans (Dextran)
3.	sodium sulfate (sodium bisulfate)
4.	Thioctic Acid (Lipoic Acid)
5.	Proteins (Proteins, Gene)
6.	JNK Mitogen-Activated Protein Kinases
7.	Phosphotransferases (Kinase)
8.	Ethanol (Ethyl Alcohol)
9.	Cyclooxygenase 2 (Cyclooxygenase-2)
10.	Paclitaxel (Taxol)

Related Therapies and Procedures

1.	Spinal Injections
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Intravenous Administration
5.	Intravitreal Injections