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IQ motif containing GTPase activating protein 1

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a calmodulin-binding rasGAP-related protein that shares 92% identity with p180 & 62% identity with IQGAP2; IQGAP1 & IQGAP2 are effectors of Cdc42 GTPase; partial amino acid sequence given in first source

Also Known As:

CYK1 protein, S cerevisiae; IQ motif containing GTPase activating protein 1, Xenopus; IQ motif containing GTPase activating protein 1, human; IQ motif containing GTPase activating protein 1, mouse; IQG1 protein, S cerevisiae; IQGAP1 protein; IQGAP1 protein, human; Iqgap1 protein, mouse; XIQGAP1 protein, Xenopus; YPL242C protein, S cerevisiae; p195 (protein); p195 protein, human

Networked: 10 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Intracellular Signaling Peptides and Proteins: 22
    - GTP-Binding Protein Regulators
      - GTPase-Activating Proteins: 333
        ras GTPase-Activating Proteins: 54
        IQ motif containing GTPase activating protein 1: 10
  - GTP-Binding Protein Regulators
    - GTPase-Activating Proteins: 333
      - ras GTPase-Activating Proteins: 54
        IQ motif containing GTPase activating protein 1: 10
- Peptides: 22950
  - Intracellular Signaling Peptides and Proteins: 22
    - GTP-Binding Protein Regulators
      - GTPase-Activating Proteins: 333
        ras GTPase-Activating Proteins: 54
        IQ motif containing GTPase activating protein 1: 10

Experts

1.	Ma, Yongyong: 2 articles (11/2014 - 12/2013)
2.	Jiang, Songfu: 2 articles (11/2014 - 12/2013)
3.	Jin, Zhouxiang: 2 articles (11/2014 - 12/2013)
4.	Huang, Jin: 2 articles (11/2014 - 12/2013)
5.	Yu, Kang: 2 articles (11/2014 - 12/2013)
6.	Zhou, Shujuan: 2 articles (11/2014 - 12/2013)
7.	Ye, Haige: 2 articles (11/2014 - 12/2013)
8.	Li, Wenji: 1 article (12/2015)
9.	Huang, Ying: 1 article (12/2015)
10.	Su, Zheng-Yuan: 1 article (12/2015)

Related Diseases

1.	Multiple Myeloma 12/01/2013 - "The present study was designed to explore the role of IQ motif-containing GTPase activating protein 1 (IQGAP1) in the cell proliferation of multiple myeloma (MM) via the MAP kinase (ERK) pathway. " 11/01/2014 - "Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation."
2.	Lung Injury 12/01/2015 - "The stability and cellular distribution of Nrf2 is tightly controlled by its inhibitory binding protein Kelch-like ECH-associated protein 1. Nrf2 signalling is also regulated by posttranslational, transcriptional, translational and epigenetic mechanisms, as well as by other protein partners, including p62, p21 and IQ motif-containing GTPase activating protein 1. Many studies have demonstrated that Nrf2 is a promising target for preventing carcinogenesis and other chronic diseases, including cardiovascular diseases, neurodegenerative diseases and pulmonary injury. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/01/2015 - "The stability and cellular distribution of Nrf2 is tightly controlled by its inhibitory binding protein Kelch-like ECH-associated protein 1. Nrf2 signalling is also regulated by posttranslational, transcriptional, translational and epigenetic mechanisms, as well as by other protein partners, including p62, p21 and IQ motif-containing GTPase activating protein 1. Many studies have demonstrated that Nrf2 is a promising target for preventing carcinogenesis and other chronic diseases, including cardiovascular diseases, neurodegenerative diseases and pulmonary injury. "
4.	Hemorrhage 01/01/2014 - "A study based on records taken at time of hoof trimming reveals a strong association between the IQ motif-containing GTPase-activating protein 1 (IQGAP1) gene and sole hemorrhage in Holstein cattle."
5.	Chronic Disease (Chronic Diseases) 12/01/2015 - "The stability and cellular distribution of Nrf2 is tightly controlled by its inhibitory binding protein Kelch-like ECH-associated protein 1. Nrf2 signalling is also regulated by posttranslational, transcriptional, translational and epigenetic mechanisms, as well as by other protein partners, including p62, p21 and IQ motif-containing GTPase activating protein 1. Many studies have demonstrated that Nrf2 is a promising target for preventing carcinogenesis and other chronic diseases, including cardiovascular diseases, neurodegenerative diseases and pulmonary injury. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Carrier Proteins (Binding Protein)
3.	Messenger RNA (mRNA)
4.	Quercetin