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NPC 18688

bradykinin B2 receptor antagonist; structure in first source

Also Known As:

NPC-18688

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - NPC 18688: 1
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - NPC 18688: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - NPC 18688: 1

Related Diseases

1.	Pathologic Processes 02/01/1996 - "7. These results demonstrate that the newly-developed and selective pseudopeptide B2 receptor antagonist, NPC 18688, although less potent than the available second generation of B2 peptide BK receptor antagonists, exhibits topical and long-lasting systemic anti-hyperalgesic properties when analysed in several models of nociception in mice, making it a useful tool for investigating the participation of BK and related kinins in physiological and pathological processes. "
2.	Pain (Aches) 02/01/1996 - "However, NPC 18688 (up to 300 nmol kg-1, i.p.), given 30 min beforehand, had no significant analgesic effect when analyzed in the tail flick and in the hot plate pain models, nor did it change the performance of animals in the rota rod test. " 02/01/1996 - "3. NPC 18688 (10-300 nmol kg-1, i.p.) caused a graded inhibition of both phases of formalin (2.5%)-induced pain, its effects being more potent in relation to the second phase of the formalin test. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Kinins
3.	Formaldehyde (Formol)
4.	Analgesics (Analgesic Drugs)