pgRNA

08/12/2023 - "In chronic hepatitis B (CHB) patients, quantification of HBV pgRNA in plasma has the potential to provide information on disease prognosis and liver injury or histopathology. "
01/01/2022 - "One hundred naïve nucleos(t)ide analog-treated patients with chronic hepatitis B were enrolled to analyze the dynamics of HBV pgRNA over 9 years. "
01/01/2022 - "The long-term dynamics of HBV pgRNA in patients with chronic hepatitis B need to be explored. "
08/12/2023 - "The study presents a novel RT-PCR assay that allows accurate measurement of plasma HBV pgRNA in chronic hepatitis B patients, even in the presence of excess HBV DNA. "
09/01/2006 - "In this study, we have developed and applied sensitive and specific quantitative real-time polymerase chain reaction (PCR) assays for the measurement of intrahepatic concentration, pgRNA production, and replicative activity of cccDNA in liver biopsy samples from 34 non-treated patients with chronic hepatitis B (CHB); 12 hepatitis B e antigen (HBeAg)(+) and 22 HBeAg(-). "

12/21/2022 - "It had been shown that transfection of in vitro-transcribed pgRNA initiated viral replication in human hepatoma cells. "
05/04/2017 - "Overexpression of miR-30c significantly inhibited HBV replication and the expressions of HBV pgRNA, capsid-associated virus DNA and Hbx in hepatoma cells. "
01/01/2016 - "However, analyses of the RNA species of human and duck hepatitis B viruses (HBV and DHBV, respectively) in hepatoma cells treated with viral DNA polymerase inhibitors revealed the genesis of novel RNA species migrating slightly faster than the full-length pgRNA. "
01/01/2021 - "Thus cccDNA, pgRNA, and HBsAg along with the viral DNA could be the therapeutic targets in the early disease stages that may improve the quality of life of chronic hepatitis B patients by impeding the progression of the disease toward hepatocellular carcinoma."
01/01/2021 - "Residual HBV DNA and pgRNA viraemia is associated with hepatocellular carcinoma in chronic hepatitis B patients on antiviral therapy."

01/01/2013 - "This study was aimed to measure hepatic pgRNA and cccDNA expression levels in various states of hepatitis B virus (HBV) infection. "
12/01/2022 - "Inoculum enrichment before infection suggests that pgRNA-containing particles drive this impact on viral replication. "
01/12/2021 - "We show that human serum culture enhanced HBV infection in Huh7.5-NTCP cells, e.g., in HS cultures, HBV pgRNA levels were increased by as much as 200-fold in comparison with FBS cultures and 19-fold in comparison with FBS+DMSO cultures. "
12/01/2019 - "These results indicate that SSc acts as a promising compound for modulating pgRNA transcription in the therapeutic strategies against HBV infection."
06/01/2013 - "Intrusion of HBV PgRNA reverse transcription in early stage of infection might appear advantageous to thwart the development of HCC."

01/01/2023 - "Measuring hepatitis B pgRNA stability using an updated automated HBV pgRNA assay with increased sensitivity."
01/01/2022 - "Long-term dynamic monitoring of serum HBV pgRNA levels has significance in hepatitis B treatment."
10/10/2010 - "Proximity between the cap and 5' epsilon stem-loop structure is critical for the suppression of pgRNA translation by the hepatitis B viral polymerase."
09/01/2008 - "The major 2.2-kb spliced pgRNA encodes a novel HBV gene product, the hepatitis B splice protein (HBSP) via a deletion and frame shift within the polymerase. "
01/01/2022 - "Pregenomic RNA (pgRNA) and hepatitis B core-related antigen (HBcrAg) play significant roles in predicting discontinuing treatment outcomes. "

03/03/2023 - "In this study, we engineered an active RNase P ribozyme, M1-S-A, targeting the overlapping region of HBV S mRNA, pre-S/L mRNA, and pregenomic RNA (pgRNA), all deemed essential for viral infection. "