HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

6- (4- isothiocyanatobenzyl)- diethylenetriamine pentaacetic acid

structure given in first source

Also Known As:

6-p-isothiocyanatobenzyl diethylene triamine penta-acetic acid; CITC DTPA; CITCDTPA

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Dwarakanath, B S: 1 article (12/2002)
2.	Figueredo, R: 1 article (12/2002)
3.	Iznaga-Escobar, N: 1 article (12/2002)
4.	Jain, V K: 1 article (12/2002)
5.	Mathew, T Lazar: 1 article (12/2002)
6.	Mishra, A K: 1 article (12/2002)
7.	Pérez-Rodríguez, R: 1 article (12/2002)
8.	Sharma, R K: 1 article (12/2002)
9.	Chérel, Michel: 1 article (02/2002)
10.	Couturier, Olivier: 1 article (02/2002)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 05/01/1996 - "Pharmacokinetics and biodistribution of samarium-153-labelled OC125 antibody coupled to CITCDTPA in a xenograft model of ovarian cancer." 05/01/1995 - "The development of stable chelating agents for metal isotopes (e.g., 90Y) such as CITC-DTPA, a benzyl-analog of DTPA, allowed us to evaluate the efficacy of 90Y-labeled HMFG1 MAb administered intraperitoneally in patients with ovarian cancer. "
2.	Neoplasms (Cancer) 12/01/2002 - "Biodistribution studies with 2-IT modified antibodies and CITC-DTPA immunoconjugates indicated high tumor uptake in both cell lines with both immunoconjugates and no accumulation of the radiolabeled antibodies in normal organs."
3.	Glioblastoma (Glioblastoma Multiforme) 12/01/2002 - "The following studies are described in this article: the 99mTc-randiolabeling of 2-iminothiolane (2-IT) modified antibodies and 6-p-isothiocyanatobenzyl- diethylene-triamine penta-acetic acid (CITC-DTPA) immunoconjugates of anti-EGF-receptor antibodies murine ior egf/r3 and humanized h-R3; the analytical methods for quality control of the radiopharmaceutical such as instant thin layer chromatography-silica gel (ITLC-SG); the biological assessment of the radiolabeled molecule using flow cytometry analysis; in vitro stability studies with cysteine and DTPA challenge and the biodistribution studies in 4NMRI xenografted nude mice with U-87 human glioblastoma multiforme and MDA-MB-468 breast cancer cell lines. "
4.	Breast Neoplasms (Breast Cancer) 12/01/2002 - "The following studies are described in this article: the 99mTc-randiolabeling of 2-iminothiolane (2-IT) modified antibodies and 6-p-isothiocyanatobenzyl- diethylene-triamine penta-acetic acid (CITC-DTPA) immunoconjugates of anti-EGF-receptor antibodies murine ior egf/r3 and humanized h-R3; the analytical methods for quality control of the radiopharmaceutical such as instant thin layer chromatography-silica gel (ITLC-SG); the biological assessment of the radiolabeled molecule using flow cytometry analysis; in vitro stability studies with cysteine and DTPA challenge and the biodistribution studies in 4NMRI xenografted nude mice with U-87 human glioblastoma multiforme and MDA-MB-468 breast cancer cell lines. "
5.	Adenocarcinoma 05/01/1996 - "This study compares the pharmacokinetics and biodistribution of 153Sm-labelled OC125 monoclonal antibody, in whole or F(ab')2 fragment form and with diethylene triamine penta-acetic acid (DTPA) or 6-p-isothiocyanatobenzyl diethylene triamine penta-acetic acid (CITCDTPA) coupling, in nude mice grafted subcutaneously with an ovarian adenocarcinoma line (SHIN-3) expressing CA125 antigen. "

Related Drugs and Biologics

1.	Pentetic Acid (DTPA)
2.	Chelating Agents
3.	Metals
4.	Isotopes
5.	pemtumomab
6.	Acetic Acid (Vinegar)
7.	6- (4- isothiocyanatobenzyl)- diethylenetriamine pentaacetic acid
8.	PENTA
9.	diethylenetriamine
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Radioimmunotherapy