neonatal Fc receptor

transcytoses IgG antibodies across enterocytes of proximal intestine to young

Also Known As:

Fc receptor, neonatal; FCGRT protein, human; Fc fragment of IgG, receptor, transporter, alpha protein, human; Fc receptor, IgG, alpha chain transporter, mouse; Fc receptors, neonatal; FcRn neonatal transfer protein; FcRn protein, human; FcRn protein, mouse; Fcgrt protein, mouse; Neonatal Fc receptor, human; neonatal Fc receptor, mouse; neonatal Fc receptors; receptor, Fc neonatal

Networked: 116 relevant articles (14 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Blumberg, Richard S: 5 articles (12/2021 - 12/2013)
2.	Roopenian, Derry C: 5 articles (11/2011 - 12/2005)
3.	Gouilleux-Gruart, Valérie: 4 articles (10/2021 - 05/2015)
4.	Smith, Bryan: 3 articles (01/2021 - 11/2017)
5.	Baker, Kristi: 3 articles (01/2018 - 12/2013)
6.	Rath, Timo: 3 articles (10/2014 - 12/2013)
7.	Mezo, Adam R: 3 articles (03/2013 - 02/2010)
8.	Zhu, Xiaoping: 3 articles (11/2011 - 03/2011)
9.	Coyne, Carolyn B: 2 articles (01/2022 - 01/2022)
10.	Howard, Kenneth A: 2 articles (01/2022 - 10/2021)

Related Diseases

1.	Autoimmune Diseases (Autoimmune Disease) 07/01/2009 - "Studies on mouse models have indicated that the neonatal Fc receptor (FcRn) plays important roles in a variety of autoimmune diseases. " 01/01/2021 - "Targeting the neonatal Fc receptor (FcRn) to treat autoimmune diseases and maternal-fetal immune cytopenias." 01/01/2021 - "In addition, there are currently ongoing studies looking at the use of antibodies targeting the neonatal Fc receptor (FcRn) in various autoimmune diseases, including TED. " 12/01/2022 - "Antagonism of the neonatal Fc receptor (FcRn) by efgartigimod has been studied in several autoimmune diseases mediated by immunoglobulin G (IgG) as a therapeutic approach to remove pathogenic IgGs. " 10/14/2022 - "Binding to the neonatal Fc receptor (FcRn) extends serum half-life of IgG, and antagonizing this interaction is a promising therapeutic approach in IgG-mediated autoimmune diseases. "
2.	Pemphigus (Pemphigus Vulgaris) 01/01/2022 - "Treatment of pemphigus vulgaris and foliaceus with efgartigimod, a neonatal Fc receptor inhibitor: a phase II multicentre, open-label feasibility trial." 12/01/2021 - "This study reveals the importance of neonatal Fc receptor in the biology of pemphigus and the potential for use of ALXN1830 in pemphigus treatment." 01/01/2022 - "Targeting the neonatal Fc receptor in pemphigus: safety first." 12/01/2021 - "Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus." 12/01/2021 - "ALXN1830 is a humanized IgG4 antibody that blocks neonatal Fc receptor interactions with IgG. A multicenter, open-label safety and tolerability phase 1b/2 trial (NCT03075904) was conducted in North America from July 2017 to January 2019 and included patients aged ≥18 years with a confirmed diagnosis of pemphigus (vulgaris or foliaceus) and active disease. "
3.	Myasthenia Gravis 01/01/2019 - "A novel treatment approach currently in clinical trials for myasthenia gravis targets the neonatal Fc receptor (FcRn). " 01/01/2023 - "These findings support the mechanism of action of neonatal Fc receptor inhibition in generalised myasthenia gravis. " 01/01/2023 - "Since there is a better understanding of the molecular structure and the biological properties of the neonatal Fc receptors (FcRn), it possesses an attractive profile in treating myasthenia gravis. " 01/01/2019 - "Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis." 01/01/2019 - "We therefore tested efgartigimod (ARGX-113), a new neonatal Fc receptor blocker, in a mouse model for MuSK myasthenia gravis. "
4.	Infections 10/30/2014 - "Enhanced neonatal Fc receptor function improves protection against primate SHIV infection." 01/01/2022 - "We show that expression of the human homologue of the primary echovirus receptor, the neonatal Fc receptor (FcRn), is not sufficient for infection of the brains of neonatal mice. " 01/01/2022 - "We show that human neonatal Fc receptor (FcRn), the primary receptor for echoviruses, is essential for intestinal infection by the enteral route and that type I IFNs control dissemination to secondary sites, including the liver. " 01/01/2017 - "We also identify that the neonatal Fc receptor (FcRn) is upregulated in the cornea following infection or injury concomitant with increased Ab perfusion. " 10/01/1996 - "The neonatal Fc receptor is not required for mucosal infection by mouse mammary tumor virus."
5.	Neoplasms (Cancer) 09/01/2022 - "It is described in the literature that the neonatal Fc receptor (FcRn) is expressed in cancer tissue and overexpressed in CRC epithelial cells. " 01/01/2022 - "Formation of conjugates and assemblies was confirmed by gel shift analysis and mass spectrometry, followed by investigation of serum stability, neonatal Fc receptor (FcRn)-mediated cellular recycling, and cancer cell killing. " 01/01/2020 - "The neonatal Fc receptor in cancer FcRn in cancer." 01/01/2014 - "This discovery extends our understanding of neonatal Fc receptors, defines a role for tumor-reactive IgGs, and identifies an avenue for the development of novel anti-cancer therapeutics." 10/01/2020 - "Albumin-conjugated drugs attain KRAS mutant cancer targeting through KRAS-enhanced macropinocytosis and intensified lysosomal degradation due to reduced neonatal Fc receptor (FcRn) expression. "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Intravenous Immunoglobulins (IVIG)
3.	Immunoglobulins (Immunoglobulin)
4.	Autoantibodies
5.	Complement System Proteins (Complement)
6.	Therapeutic Uses
7.	Rheumatoid Factor
8.	IgG Receptors (Fc gamma RI)
9.	Immunoglobulin Fc Fragments
10.	glucose-mannose-glucose

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Precision Medicine