4-methylcoumarin 7-O-sulfamate

inhibits estrone sulfatase; structure in first source

Also Known As:

COUMATE

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        4-methylcoumarin 7-O-sulfamate: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        4-methylcoumarin 7-O-sulfamate: 4
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - 4-methylcoumarin 7-O-sulfamate: 4
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - 4-methylcoumarin 7-O-sulfamate: 4

Experts

1.	Jubie, Selvaraj: 1 article (01/2020)
2.	Naresh, Podila: 1 article (01/2020)
3.	Natarajan, Jawahar: 1 article (01/2020)
4.	Sundar, Shyam: 1 article (01/2020)
5.	Wadhwani, Ashish: 1 article (01/2020)
6.	Yadav, Neetu: 1 article (01/2020)
7.	Davies, William: 1 article (10/2014)
8.	Eddy, Jessica B: 1 article (10/2014)
9.	Humby, Trevor: 1 article (10/2014)
10.	Ojarikre, Obah A: 1 article (10/2014)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/01/1996 - "COUMATE did not stimulate the growth of MCF-7 breast cancer cells or uteri of ovariectomized rats, in contrast to estrone-3-O-sulfamate. " 11/01/1996 - "Because nonsteroidal steroid sulfatase inhibitors may offer some advantage for use in the treatment of breast cancer, 4-methylcoumarin-7-O-sulfamate (COUMATE) was synthesized and shown to be active in vitro. " 01/01/2020 - "A novel class of hybrids having coumate and benzimidazolone scaffolds were designed to mimic BRCA 1 protein, suppressing the tumor activity of breast cancer cells. " 03/26/1998 - "Hence, highly potent sulfamate-based inhibitors of steroid sulfatase, such as EMATE, COUMATE, and 24, possess therapeutic potential and will allow the importance of estrogen formation in breast tumors via the E1-STS pathway to be assessed. "
2.	Neoplasms (Cancer) 01/01/2020 - "A novel class of hybrids having coumate and benzimidazolone scaffolds were designed to mimic BRCA 1 protein, suppressing the tumor activity of breast cancer cells. "
3.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 10/01/2014 - "We examined whether deletion of the Sts gene in the 39,X(Y*)O mouse model, or pharmacological manipulation of the STS axis, via administration of the enzyme substrate dehydroepiandrosterone sulfate or the enzyme inhibitor COUMATE, influenced behavior in a novel murine analog of the stop-signal reaction time task used to detect inhibitory deficits in individuals with ADHD. "

Related Drugs and Biologics

1.	Steryl-Sulfatase (Steroid Sulfatase)
2.	Dehydroepiandrosterone Sulfate
3.	Proteins (Proteins, Gene)
4.	Estrogens (Estrogen)
5.	Enzymes
6.	Enzyme Inhibitors (Inhibitors, Enzyme)
7.	estrone-3-O-sulfamate
8.	benzimidazolone
9.	sulfamic acid (ammonium sulfamate)