sibiromycin

aminoglycoside antibiotic isolated from Streptosporangium sibiricum has antineoplastic properties & inhibits growth of Bacillus mycoides, Bacillus subtilis, Staphylococcus aureus & Escherichia coli; minor descriptor (75-86); on-line & INDEX MEDICUS search ANTIBIOTICS, ANTINEOPLASTIC (75-86)

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gerratana, Barbara: 2 articles (06/2012 - 05/2009)
2.	Khullar, Ankush: 2 articles (06/2012 - 05/2009)
3.	Li, Wei: 2 articles (06/2012 - 05/2009)
4.	Reixach, Natàlia: 1 article (06/2012)
5.	Yonemoto, Isaac T: 1 article (06/2012)
6.	Chou, Shenchieh: 1 article (05/2009)
7.	Sacramo, Ashley: 1 article (05/2009)

Related Diseases

1.	Cardiotoxicity 05/01/2009 - "Despite the promising antitumor properties clinical trials of sibiromycin were precluded by the cardiotoxicity effect in animals attributed to the presence of the C-9 hydroxyl group. " 06/15/2012 - "Among pyrrolobenzodiazepines, cardiotoxicity is associated with hydroxylation at position 9. Deletion of the methyltransferase gene sibL abolishes the production of sibiromycin. " 06/15/2012 - "Pursuit of the actinomycete pyrrolobenzodiazepine natural product sibiromycin as a chemotherapeutic agent has been limited by its cardiotoxicity. "
2.	Neoplasms (Cancer) 05/01/1972 - "[Comparison of bruneomycin and sibiromycin efficacy in the treatment of mice with transplantable tumors]."

Related Drugs and Biologics

1.	Hydroxyl Radical
2.	Streptonigrin (Nigrin)
3.	Methyltransferases
4.	pyrrolo(2,1-c)(1,4)benzodiazepine