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phendimetrazine (Bontril)

Subscribe to New Research on phendimetrazine

minor descriptor (66-86); file maintained to MORPHOLINES (66-86); on-line & INDEX MEDICUS search MORPHOLINES (66-86); RN given refers to parent cpd without isomeric designation

Also Known As:

Bontril; Melfiat; X-Trozine; Adipost; Amarin brand of phendimetrazine tartrate; Di-Ap-Trol; Dyrexan; Foy brand of phendimetrazine tartrate; Hyrex; Jones brand of phendimetrazine tartrate; Numark brand of phendimetrazine tartrate; Obezine; Prelu-2; Roberts brand of phendimetrazine tartrate; Roxane brand of phendimetrazine tartrate; Shire brand of phendimetrazine tartrate; Trimen brand of phendimetrazine tartrate; Trimstat; Vortech brand of phendimetrazine tartrate; Wehless; Weightrol; Western Research brand of phendimetrazine tartrate; phendimetrazine hydrochloride; phendimetrazine hydrochloride, (2S-trans)-isomer; phendimetrazine tartrate; phendimetrazine tartrate, (2S-trans(R-(R*,R*)))-isomer; phendimetrazine tartrate, (R-(R*,R*))-isomer; phendimetrazine, (2R-cis)-isomer; phendimetrazine, (2S-trans)-isomer; phendimetrazine, trans(+-)-isomer

Networked: 10 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Oxazines: 2
    - Morpholines: 4
      - phendimetrazine: 10

Experts

1.	Gonzalez, Gisselle: 1 article (01/2008)
2.	Landau, Danny: 1 article (01/2008)
3.	Jackson, Judith: 1 article (01/2008)
4.	Chung, J K: 1 article (04/2007)
5.	Lee, Woojin: 1 article (04/2007)
6.	Ohn, Young Hoon: 1 article (04/2007)
7.	Roh, Kyu Hwa: 1 article (04/2007)
8.	Chang, Jee Ho: 1 article (04/2007)
9.	Yakoby, M: 1 article (03/2006)
10.	Lokhandwala, N: 1 article (03/2006)

Related Diseases

1.	Weight Loss (Weight Reduction) 07/07/1962 - "Study of phendimetrazine bitartrate as an appetite suppressant in relation to dosage, weight loss and side effects." 01/01/2008 - "Phendimetrazine is a medication currently being used to help patients with weight loss. " 10/01/1998 - "A 47-year-old mildly obese female began a weight reduction program that included anorectic therapy with phentermine and phendimetrazine. " 10/01/2000 - "This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylpropion, mazindol, and phentermine), as well as over-the-counter adrenergic drugs (phenylpropanolamine and ephedrine); recent clinical studies documenting the safety and efficacy of a new medication for obesity treatment, sibutramine, recently approved by the Food and Drug Administration for long-term use; and recent studies characterizing the valvulopathy associated with fenfluramine and dexfenfluramine, serotonergic medications for obesity which have been removed from the markets."
2.	Obesity 03/01/1968 - "Sustained-action phendimetrazine in obesity." 08/01/1961 - "Comparative study of phenmetrazine and phendimetrazine in the management of obesity." 10/01/1998 - "Despite the recent withdrawal of two anorectic agents due to data linking them to severe cardiac and pulmonary disease, the appetite suppressants phentermine and phendimetrazine remain in widespread usage for the treatment of obesity. " 10/01/2000 - "This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylpropion, mazindol, and phentermine), as well as over-the-counter adrenergic drugs (phenylpropanolamine and ephedrine); recent clinical studies documenting the safety and efficacy of a new medication for obesity treatment, sibutramine, recently approved by the Food and Drug Administration for long-term use; and recent studies characterizing the valvulopathy associated with fenfluramine and dexfenfluramine, serotonergic medications for obesity which have been removed from the markets."
3.	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 04/01/2007 - "Sympathomimetic drugs such as phendimetrazine and ephedrine are used as anorexiants and may induce transient myopia associated with ciliochoroidal effusion, shallow anterior chamber, and acute angle-closure glaucoma."
4.	Rhabdomyolysis 03/01/2006 - "To our knowledge, this is the first reported case of rhabdomyolysis from administration of therapeutic amounts of phendimetrazine tartrate. " 03/01/2006 - "Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate." 03/01/2006 - "We present a case of rhabdomyolysis and myoglobinuria developing in a 23-year-old patient after oral administration of phendimetrazine tartrate for 3 days in suggested therapeutic doses. "
5.	Interstitial Nephritis (Tubulointerstitial Nephritis) 10/01/1998 - "This case represents the first report of acute interstitial nephritis associated with phentermine or phendimetrazine." 10/01/1998 - "Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine."

Related Drugs and Biologics

1.	Phentermine (Adipex-P)
2.	Ephedrine
3.	Dexfenfluramine (Redux)
4.	Adrenergic Agents (Adrenergic Drugs)
5.	Phenylpropanolamine (Dexatrim)
6.	Mazindol (Mazanor)
7.	Fenfluramine
8.	Diethylpropion (Amfepramone)
9.	Benzphetamine (Benzfetamine)
10.	sibutramine (Meridia)

Related Therapies and Procedures

1.	Oral Administration