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methsuximide (mesuximide)

Subscribe to New Research on methsuximide

anticonvulsant effective in petit mal & psychomotor epilepsy; has a number of unpleasant & toxic side effects; minor descriptor (75-86); on-line & INDEX MEDICUS search SUCCINIMIDES (75-86); RN given refers to parent cpd without isomeric designation

Also Known As:

mesuximide; Celontin; Petinutin; mesuximid; N,2-dimethyl-2-phenylsuccinimide; Parke David brand of methsuximide; Pfizer brand of methsuximide; Warner-Lambert brand of methsuximide; methsuximide, (+)-isomer; methsuximide, (+-)-isomer; methsuximide, (-)-isomer

Networked: 15 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Besag, F M: 1 article (12/2001)
2.	Vasey, M: 1 article (12/2001)
3.	Berry, D J: 1 article (12/2001)
4.	Strassburg, H M: 1 article (03/2001)
5.	Sigler, M: 1 article (03/2001)
6.	Boenigk, H E: 1 article (03/2001)

Related Diseases

1.	Seizures (Seizure) 03/01/1996 - "has now had complete seizure control on methsuximide monotherapy, a total of 1200 mg a day, for 7 years with the exception of one seizure event occurring on an attempted discontinuation of methsuximide after being 5 years seizure free. " 03/01/1996 - "All five patients have been seizure free with the use of methsuximide and four out of five are now on methsuximide monotherapy with good success. " 04/01/1983 - "Methsuximide for complex partial seizures: efficacy, toxicity, clinical pharmacology, and drug interactions." 06/01/1981 - "Methsuximide appeared to be an effective and generally well tolerated adjunct medication in the management of complex partial seizures." 06/01/1981 - "Seizure control was optimal at methsuximide doses of 9.5 to 11.0 mg per kilogram per day and plasma levels of 20 to 24 micrograms per milliliter. "
2.	Epilepsy (Aura) 03/01/2001 - "Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood." 03/01/2001 - "The efficacy and safety of methsuximide (MSM) was evaluated in children with intractable epilepsies in a prospective uncontrolled study. " 07/01/1977 - "[Methsuximide in the treatment of epilepsies (author's transl)]." 03/01/1958 - "Celontin in patients with refractory epilepsy." 07/01/1957 - "Use of celontin in the treatment of mixed epilepsy."
3.	Absence Epilepsy (Absence Seizure) 06/01/1960 - "Treatment of petit mal epilepsy with the new succinimides: PM 680 and celontin. " 06/01/1990 - "Phensuximide (PSX), methsuximide (MSX) and ethosuximide (ESX) are succinimide antiepileptic agents used worldwide in the treatment of absence seizures. "
4.	Juvenile Myoclonic Epilepsy 03/01/1996 - "Methsuximide therapy of juvenile myoclonic epilepsy."
5.	Restless Legs Syndrome (Restless Legs) 01/01/1988 - "We report two patients with complex partial and secondarily generalized seizures, who developed restless legs while taking methsuximide and phenytoin. "

Related Drugs and Biologics

1.	Valproic Acid (Valproate, Semisodium)
2.	Phenytoin (Dilantin)
3.	Anticonvulsants (Antiepileptic Drugs)
4.	methsuximide (mesuximide)
5.	Succinimides
6.	Primidone (Sertan)
7.	Phenobarbital (Luminal)
8.	Ethosuximide (Zarontin)
9.	Carbamazepine (Tegretol)
10.	phensuximide