actinobolin

active against broad spectrum of bacteria & variety of rodent neoplasms; minor descriptor (75-85); on-line & Index Medicus search ANTIBIOTICS (75-85); RN given refers to (3R- (3alpha,4alpha(S*),4abeta,5beta,6alpha))-isomer

Also Known As:

2-amino-N-(3,4,4a,5,6,7-hexahydro-5,6,8-trihydroxy-3-methyl-1-oxo-1H-2-benzopyran-4-yl)propanamide; actinobolin sulfate (1:1); actinobolin sulfate (3R) (2:1); actinobolin sulfate, ((3alpha,4alpha(S*),4abeta,5beta,6alpha))-isomer

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - actinobolin: 8

Related Diseases

1.	Periodontal Diseases (Periodontal Disease) 01/01/1972 - "These observations suggest that actinobolin may be effective in the treatment of periodontal disease." 01/01/1972 - "Actinobolin was evaluated in vitro by a paper disc-agar diffusion method for inhibitory activity against mixed microbial cultures obtained from patients with periodontal disease and against pure bacterial cultures tentatively identified as strains of Bacteroides melaninogenicus, Fusobacterium fusiforme, Leptotrichia buccalis, and Veillonella parvula. " 01/01/1972 - "In vitro evaluation of actinobolin as an antibiotic for the treatment of periodontal disease." 09/01/1972 - "In vitro comparison of actinobolin and other antibiotics used in the treatment of periodontal disease and dental caries. "
2.	Neoplasms (Cancer) 01/01/1959 - "The effects of actinobolin on the growth of human tumors H.S. " 01/01/1959 - "The effect of actinobolin on a spectrum of tumors."
3.	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 10/01/1992 - "Suppression of experimental autoimmune myasthenia gravis with new immunosuppressants: 15-deoxyspergualin and actinobolin."
4.	Leukemia 01/01/1959 - "The effects of actinobolin on transplanted mouse leukemias."
5.	Herpes Simplex 10/01/1984 - "Actinobolin, amicetin and tetracenomycin C were also active against viruses other than herpes simplex."

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Immunosuppressive Agents (Immunosuppressants)
3.	Agar
4.	gusperimus
5.	tetracenomycin C
6.	amicetin