piericidin A

pyridine-substituted fatty alcohol antibiotic; minor descriptor (75-85); on-line & Index Medicus search ANTIBIOTICS (75-85); RN given refers to (S-(R*,R*-(all-E)))-isomer

Also Known As:

2-(10-hydroxy-3,7,9,11-tetramethyl-2,4,7,11-tridecatetraenyl)-5,6-dimethoxy-3-methyl-4-pyridinol; AR 054; AR-054; piericidin A1; 4(1H)-Pyridinone, 2-((2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl)-5,6-dimethoxy-3-methyl-

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - piericidin A: 9

Experts

1.	Chen, Yulian: 2 articles (01/2021 - 01/2019)
2.	Li, Kunlong: 2 articles (01/2021 - 01/2019)
3.	Liang, Zhi: 2 articles (01/2021 - 01/2019)
4.	Liu, Yonghong: 2 articles (01/2021 - 01/2019)
5.	Tang, Lan: 2 articles (01/2021 - 01/2019)
6.	Zhan, Zhikun: 2 articles (01/2021 - 01/2019)
7.	Zhou, Xuefeng: 2 articles (01/2021 - 01/2019)
8.	Dai, Fahong: 1 article (01/2021)
9.	Gu, Tanwei: 1 article (01/2021)
10.	Jiang, Huanguo: 1 article (01/2021)

Related Diseases

1.	Tauopathies 01/01/2014 - "This study shows that exposure to piericidin A aggravates the course of genetically determined tau pathology, providing experimental support for the concept of gene-environment interaction in the etiology of tauopathies."
2.	Carcinoma (Carcinomatosis) 01/01/2016 - "We found that inhibitors of mitochondrial respiratory chain complexes III (myxothiazol) and I (piericidin A) in some epithelial carcinoma cell lines induce transcription of the p53-responsive SESN2 gene that plays an important role in stress response and homeostatic regulation. " 01/01/2021 - "Reported as two antirenal cell carcinoma (RCC) drug candidates, marine-derived compounds piericidin A (PA) and glucopiericidin A (GPA) exhibit hepatotoxicity in renal carcinoma xenograft mice. " 04/01/2008 - "Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator."
3.	Prostatic Neoplasms (Prostate Cancer) 09/24/2018 - "EGF: Epidermal growth factor; PDGF: Platelet-derived growth factor; CRPC: Castration-resistant prostate cancer; AR: Androgen receptor; FTase: Farnesyl transferase; 5-LOX: 5-Lipoxygenase; LT: Leukotriene; CysLT1: Cysteinyl leukotriene receptor 1; GPA: Glucopiericidin A; PA: Piericidin A; XN: Xanthohumol; VCP: Valosin-containing protein; ACACA: Acetyl-CoA carboxylase-α."
4.	Neoplasms (Cancer) 01/01/2019 - "By exploring the mechanisms of two representative natural piericidin compounds, piericidin A (PA) and glucopiericidin A (GPA), peroxiredoxin 1 (PRDX1) is detected as a potential target by transcriptome data of PA-treated ACHN cells, as well as the paired RCC tumor versus adjacent nontumor tissues. "
5.	Multiple Myeloma 01/01/2013 - "Synthetic lehualide B is shown to be an effective inhibitor of complex I of the mitochondrial electron transport chain, with potency similar to that observed for the terrestrial natural products piericidin A1 and rotenone, an observation that led to the discovery that piericidin A1 is also selectively cytotoxic toward human multiple myeloma cells. "

Related Drugs and Biologics

1.	glucopiericidin A
2.	Glucose (Dextrose)
3.	Peroxiredoxins
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Leukotrienes
6.	Transferases
7.	Rotenone
8.	Androgen Receptors (Androgen Receptor)
9.	Platelet-Derived Growth Factor
10.	Etoposide (VP 16)

Related Therapies and Procedures

1.	Castration