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imidazole mustard (BIC)

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inhibitor of purine nucleoside synthesis; minor descriptor (77-84); on-line & Index Medicus search NITROGEN MUSTARD COMPOUNDS (77-84); RN given refers to parent cpd

Also Known As:

BIC; 5-(3,3-bis(2-chloroethyl)-1-triazeno)imidazole-4-carboxamide; BIC mustard; MCTIC; NSC 82,196; NSC-82196; TIC mustard; imidazole mustard, hydrochloride; imidazole mustard, monohydrochloride

Networked: 244 relevant articles (10 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Halogenated Hydrocarbons: 31
    - Mustard Compounds: 2
      - Nitrogen Mustard Compounds: 1
        imidazole mustard: 244

Experts

1.	Kim, Jong Oh: 3 articles (06/2015 - 06/2012)
2.	Artzi, Zvi: 3 articles (07/2011 - 10/2007)
3.	Rohrer, Michael D: 3 articles (07/2011 - 10/2007)
4.	Weinreb, Miron: 3 articles (07/2011 - 10/2007)
5.	Kozlovsky, Avital: 3 articles (07/2011 - 10/2007)
6.	Tal, Haim: 3 articles (07/2011 - 10/2007)
7.	Tam, Wayne: 3 articles (12/2009 - 05/2002)
8.	Jackson, Barbara J: 3 articles (02/2008 - 06/2004)
9.	Riggs, Dale R: 3 articles (02/2008 - 06/2004)
10.	McFadden, David W: 3 articles (02/2008 - 06/2004)

Related Diseases

1.	Seizures (Seizure) 08/26/1985 - "A comparison of the pA2 values for the various convulsant/anticonvulsant combinations suggested the following conclusions: (i) the sequence of events leading to minimal clonic seizures evoked by PTZ or PIC involves a common receptor, (ii) BIC acts through a different receptor, and (iii) Schild plot analysis of the antagonism between convulsant and anticonvulsant is in agreement with their antagonism in vitro studies. " 02/01/2013 - "Pretreatment with KET (40 mg/kg) prevented BIC seizures and reverted [(3)H]-QNB binding changes induced by BIC administration. " 11/01/2006 - "Injection of BIC alone (versus vehicle) into the VB also blocked seizure aggravation following systemic administration of CBZ (15 mg/kg i.p.). " 01/01/2006 - "Ligand binding was modified not only by a convulsant BIC dose but also by a subconvulsant dose, indicating that changes are not attributable to the seizure process itself. " 01/01/2006 - "After convulsant BIC dose, which invariably led to generalized tonic-clonic seizures, binding increased 36% and 15% to cerebellar and striatal membranes respectively, but decreased 12% to hippocampal membranes. "
2.	Wounds and Injuries (Trauma) 02/01/2014 - "The study estimates that the HCS was associated with a reduction in the number of acute injuries/illnesses due to chemical injury exposure events over the background rate in the range 107,569-459,395 (Hudson method/modified BIC model) depending on whether the HCS is treated as a marginal or sole factor in the decrease. " 01/01/2011 - "Their predictive performances were then assessed against existing TRISS models on the unweighted NSP, National Trauma Data Bank (NTDB), and New Zealand Database (NZDB) samples using area under the Receiver Operating Characteristic curve (AUC) and Bayesian Information Criterion (BIC) statistics. " 06/01/2004 - "The purpose of this study was to determine whether BIC/ MAN is effective in preventing RF in patients with rhabdomyolysis caused by trauma. " 02/01/2013 - "As with several recent studies of adult trauma victims, we found a slight advantage for the Dysphoric Arousal model over the other models on the PTSD-RI, with BIC differences exceeding 300 points. " 11/01/2005 - "This study was performed to evaluate the effects of 0.9% saline (SAL), 0.9% saline + sodium bicarbonate + mannitol (SAL/BIC/MAN), and hypertonic saline-dextran (HSD) on hemodynamic variables, tissue blood flow, and oxidant injuries in experimental traumatic rhabdomyolysis (TR) in rats subjected allogeneic muscle extract infusion. "
3.	Neoplasms (Cancer) 06/01/2015 - "The IRI-BIC showed a dose-dependent cytotoxicity in SCC-7 and A-549 cancer cell lines. " 06/15/2013 - " In conclusion, we provide the first evidence that STAT5 drives expression of oncogenic BIC/miR-155 in cancer. " 01/01/2012 - "In this article, we report some novel UVs not contained in the BIC database and explore their impact in cancer predisposition based on a structural approach." 11/15/2011 - "Using BIC-seq, we identified hundreds of CNVs as small as 40 bp in the cancer genome sequenced at 10× coverage, whereas we could only detect large CNVs (> 15 kb) in the array comparative genomic hybridization profiles for the same genome. " 02/01/2010 - "Model 1 produced reasonable and robust fits for all datasets and was judged best by the BIC for 16 of 26 tumor scans. "
4.	Rhabdomyolysis 06/01/2004 - "The standard of administering BIC/MAN to patients with post-traumatic rhabdomyolysis should be reevaluated." 06/01/2004 - "The purpose of this study was to determine whether BIC/ MAN is effective in preventing RF in patients with rhabdomyolysis caused by trauma. " 06/01/2004 - "The combination of bicarbonate and mannitol (BIC/MAN) is commonly used to prevent renal failure (RF) in patients with rhabdomyolysis despite the absence of sufficient evidence validating its use. " 11/01/2005 - "This study was performed to evaluate the effects of 0.9% saline (SAL), 0.9% saline + sodium bicarbonate + mannitol (SAL/BIC/MAN), and hypertonic saline-dextran (HSD) on hemodynamic variables, tissue blood flow, and oxidant injuries in experimental traumatic rhabdomyolysis (TR) in rats subjected allogeneic muscle extract infusion. "
5.	Hyperalgesia 01/01/2010 - "But, allodynia induced by BIC was not relieved by any amino acid. " 06/01/2001 - "Allodynia was sustained for up to 2 h with repeated BIC application without any detectable change in the location or area of peripheral sensitization. " 06/01/2001 - "BIC-allodynia was dose-dependent, yielding ED(50)'s (95% CI's) of 45 ng (31-65) for MAP; 68 ng (46-101) for HR and 76 ng (60-97) for MR. " 06/01/2001 - "Unilateral application of BIC (0.1 microg in 0.1 microl) to the L5 or L6 spinal segment induced a highly localized allodynia (e.g. " 03/01/2001 - "BIC-allodynia was reproduced by i.t. "

Related Drugs and Biologics

1.	Bicuculline
2.	Pentylenetetrazole (Metrazol)
3.	N-Methylaspartate (NMDA)
4.	Picrotoxin
5.	Glycine (Aminoacetic Acid)
6.	Muscimol
7.	Phenytoin (Dilantin)
8.	topiramate (Topamax)
9.	Convulsants
10.	Taurine

Related Therapies and Procedures

1.	Immunotherapy
2.	Drug Therapy (Chemotherapy)
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
4.	Peritoneal Dialysis
5.	Injections