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diftalone
Also Known As:
L 5418; aladione; phthalazino-(2,3-b)-phthalazine-5,12(7H,14H)-dione
Networked:
14
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridazines: 11
diftalone: 14
Related Diseases
1.
Rheumatoid Arthritis
01/01/1976 - "
Long-term controlled clinical trial of a new anti-inflammatory drug, diftalone, in rheumatoid arthritis.
"
12/01/1974 - "
Therapeutic activity of diftalone in rheumatoid arthritis: a short-term controlled evaluation.
"
12/01/1974 - "
Plasma levels of diftalone during treatment and their relationship with therapeutic activity in rheumatoid arthritis.
"
01/01/1977 - "
Diftalone seems to be an effective and safe anti-inflammatory agent in the treatment of rheumatoid arthritis.
"
01/01/1976 - "
In this long-term study, diftalone demonstrated that its effectiveness and safety in the treatment of rheumatoid arthritis are clearly comparable to those of indomethacin.
"
2.
Inflammation (Inflammations)
01/01/1978 - "
[Verification of the effect of diftalone on the inflammation caused by subcutaneous injection of microcrystalline monosodium urate].
"
05/01/1978 - "
[Limitations of the isotopic evaluation of the effects of diftalone and indomethacin on inflammation induced with subcutaneous injection of microcrystals of monosodic urate].
"
3.
Subacute Thyroiditis (Thyroiditis, De Quervain)
01/01/1977 - "
Following our experience in thirty patients we suggest that diftalone can be considered a treatment of choice in patients with subacute thyroiditis.
"
01/01/1977 - "
During 1974 and 1975 thirty patients with subacute thyroiditis referred to us were treated with diftalone (Aladione), a new non-steroidal anti-inflammatory drug, at a daily oral dose of 750 mg. The average treatment lasted 39 days (range 15-100), the mean age of the patients was 43-5 years (range: 22-70).
"
01/01/1977 - "
Aladione (diftalone) in the treatment of subacute thyroiditis.
"
4.
Neoplasms (Cancer)
01/01/1984 - "
Diftalone treatment at the highest dose was hepatotoxic and induced hepatocellular tumors in females, angiomas of the liver in males, and angiosarcomas of the liver in male and female mice.
"
5.
Hemangiosarcoma (Angiosarcoma)
01/01/1984 - "
Diftalone treatment at the highest dose was hepatotoxic and induced hepatocellular tumors in females, angiomas of the liver in males, and angiosarcomas of the liver in male and female mice.
"
Related Drugs and Biologics
1.
Anti-Inflammatory Agents (Anti-Inflammatories)
2.
Indomethacin (Indometacin)
3.
diftalone
4.
Uric Acid (Urate)
5.
Antirheumatic Agents (DMARD)
6.
Phenylbutazone (Butazolidin)
7.
Collagen
8.
Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
Related Therapies and Procedures
1.
Subcutaneous Injections