dicarbine

minor descriptor (77-84); on-line & Index Medicus search CARBOLINES (77-84); RN given refers to parent cpd without isomeric designation

Also Known As:

(-)-stobadin; (-)-stobadin dihydrochloride; (-)-stobadine; (-)-stobadine dihydrochloride; 2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-1H-pyrido(4,3-b)indole; DH 1011; DH-1011; DP 10131; DP-1031; carbidine; dicarbine dihydrochloride; dicarbine dihydrochloride, (+)-isomer; dicarbine dihydrochloride, (cis)-(+)-isomer; dicarbine dihydrochloride, (cis)-(-)-isomer; dicarbine dihydrochloride, (trans)-isomer; dicarbine fumarate (1:1); dicarbine hydrochloride; dicarbine oxalate (1:1), (cis)-(+)-isomer; dicarbine, (cis)-(+)-isomer; dicarbine, (cis)-(+-)-isomer; dicarbine, (cis)-(-)-isomer; stobadin; stobadin dihydrochloride; stobadin dipalmitate; stobadine; stobadine dihydrochloride; stobadine dipalmitate

Networked: 58 relevant articles (7 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Carbolines: 283
      - dicarbine: 58
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Carbolines: 283
        dicarbine: 58
  - 3-Ring Heterocyclic Compounds
    - Carbolines: 283
      - dicarbine: 58

Experts

1.	Stefek, Milan: 8 articles (07/2011 - 01/2004)
2.	Karasu, Cimen: 7 articles (05/2008 - 01/2004)
3.	Mach, Mojmír: 3 articles (09/2017 - 12/2006)
4.	Ari, Nuray: 3 articles (07/2011 - 01/2007)
5.	Stolc, S: 3 articles (05/2008 - 01/2003)
6.	Navarová, J: 3 articles (01/2007 - 03/2004)
7.	Gajdosik, A: 3 articles (11/2002 - 01/2000)
8.	Gajdosikova, A: 3 articles (11/2002 - 01/2000)
9.	Stefek, M: 3 articles (11/2002 - 01/2000)
10.	Majekova, Magdalena: 2 articles (01/2016 - 05/2008)

Related Diseases

1.	Ischemia 05/01/1998 - "Our previous study showed that stobadine is effective against ischemia/reperfusion-induced gastric mucosal injury. " 12/01/2005 - "The goal of the study was to monitor the antioxidative effect of stobadine derivative in the conditions of ischemia-reperfusion of laboratory rat kidney tissue. " 12/01/2005 - "The goal of the study was to monitor the antioxidative effect of stobadine derivative under conditions of ischemia-reperfusion of laboratory rat kidney tissue. " 05/07/2008 - "Stobadine-induced hastening of sensorimotor recovery after focal ischemia/reperfusion is associated with cerebrovascular protection." 01/01/1999 - "Stobadine pretreated animals were infused with 2 mg/kg stobadine 30 minutes prior to ischemia, while control animals received vehicle. "
2.	Brain Ischemia (Cerebral Ischemia) 01/01/1999 - "This study was designed to test possible protective effects of stobadine in a canine model of global cerebral ischemia. " 06/01/1995 - "Experimental studies of some microrheological factors in serious brain ischemia after stobadine pretreatment." 05/07/2008 - "The beneficial effect of stobadine underlines a link between vascular protection, neuronal protection and sensorimotor recovery that could become a promising pharmacological target in the treatment of cerebral ischemia." 01/01/1999 - "In summary, we conclude that stobadine protects both cerebral microcirculation and neurons from injury induced by global cerebral ischemia and reperfusion." 09/15/1992 - "Short cerebral ischemia and subsequent reperfusion and treatment with stobadine."
3.	Hyperglycemia 07/01/2011 - "Stobadine treatment significantly reduced the severity of hyperglycemia, heart and kidney weights, systolic blood pressure, and attenuated diabetes-induced loss in body weight gain. " 01/01/2004 - "Stobadine and vitamin E separately produced, to a similar degree, a reduction in diabetes-induced hyperglycemia. " 01/01/2007 - "The results are in accordance with the pro-oxidant role of chronic hyperglycemia, and the ability of stobadine to attenuate protein oxidation and improving tissue reductive capacity may account, at least partly for its observed beneficial effects on tissue function in diabetes." 04/01/2001 - "Moreover, the effect of the pyridoindole antioxidant stobadine ((-)-cis-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole) on the changes induced by the 8-month hyperglycemia were studied. " 07/01/2007 - "Because hyperglycemia-induced oxidative stress may be a cause of retinopathy, this study examined the hypothesis that administration of exogenous antioxidants, stobadine (ST) and vitamin E (vitE), can restore retinal abnormalities in experimental diabetes. "
4.	Wounds and Injuries (Trauma) 10/01/2006 - "3. In a mice model of head trauma, some of the new stobadine derivatives administered i.v. immediately after the trauma, significantly improved sensomotoric outcome in the animals assessed 1 h later. " 01/01/1999 - "stobadine, nitrosopine, ACE inhibitors) suggest that smooth muscle tissues are useful models to study ROS action and drug intervention in ROS induced injuries."
5.	Body Weight (Weight, Body) 06/01/1994 - "Induction of micronuclei was studied 40 h post irradiation in peripheral blood reticulocytes of male mice treated or not with stobadine dipalmitate (70.07 mg/kg body weight) at two time intervals (2 h or 1 h) prior to and immediately after 6.5 Gy 60Co exposure. " 07/01/2011 - "Stobadine treatment significantly reduced the severity of hyperglycemia, heart and kidney weights, systolic blood pressure, and attenuated diabetes-induced loss in body weight gain. " 01/01/1999 - "Previous work has shown, that stobadine-hydrochloride (-)cis-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-14-pyrido(4,3b) indole administered in a single dose 2 mg/kg of body weight reduces cardiotoxic effect of isoproterenol (1 mg/kg) as shown by lowered serum enzyme activities of AST, CPK, LDH and ALT. "

Related Drugs and Biologics

1.	Antioxidants
2.	SMe1EC2
3.	Neuroprotective Agents
4.	Vitamin E
5.	Melatonin
6.	Protective Agents
7.	Retinaldehyde (Retinal)
8.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
9.	Acids
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Investigational Therapies (Experimental Therapy)
2.	Therapeutics
3.	Self Administration (Administration, Self)
4.	Ligation
5.	Oral Administration