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malaoxon

minor descriptor (72-83); on-line & Index Medicus search MALATHION/AA (72-83)

Also Known As:

succinic acid, mercapto-, diethyl ester, dimethyl phosphate

Networked: 12 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphates: 1942
    - Organothiophosphates: 1
      - Malathion: 447
        malaoxon: 12
  - Organothiophosphorus Compounds
    - Organothiophosphates: 1
      - Malathion: 447
        malaoxon: 12
- Sulfur Compounds: 278
  - Organothiophosphorus Compounds
    - Organothiophosphates: 1
      - Malathion: 447
        malaoxon: 12

Experts

1.	Alfredo Ortega-Clemente, Luis: 1 article (01/2018)
2.	Martínez-Aguilar, Karina: 1 article (01/2018)
3.	Pérez-Legaspi, Ignacio Alejandro: 1 article (01/2018)
4.	Ramírez-Fuentes, Eustacio: 1 article (01/2018)
5.	Trujillo-Tapia, Ma Nieves: 1 article (01/2018)
6.	Brennan, James Andrew: 1 article (05/2014)
7.	Cao, Chuanwang: 1 article (05/2014)
8.	Fang, Kui: 1 article (05/2014)
9.	Pan, Yiou: 1 article (05/2014)
10.	Shang, Qingli: 1 article (05/2014)

Related Diseases

1.	Neoplasms (Cancer) 06/01/1985 - "For the malaoxon study, the only difference between the original and subsequent interpretations was for C-cell neoplasms of the thyroid gland, in that the NTP concluded there was equivocal evidence of carcinogenicity for male and female F344 rats." 06/01/1985 - "Benign and malignant neoplasms at all sites, and in the endocrine organs, were increased in Fischer-344 male and female rats ingesting malaoxon. "
2.	Carcinogenesis 06/01/1985 - "Malathion and malaoxon: histopathology reexamination of the National Cancer Institute's carcinogenesis studies."
3.	Neuroblastoma 03/13/1998 - "Therefore, this study examined concentration-related OP-induced inhibition of CbxE in human SH-SY5Y and mouse NB41A3 neuroblastoma cells with 11 active esterase inhibitors: paraoxon, malaoxon, chlorpyrifos-oxon, tolyl saligenin phosphate (TSP), phenyl saligenin phosphate (PSP), diisopropyl phosphorofluoridate (DFP), mipafox, dichlorvos, trichlorfon, dibutyryl dichlorovinyl phosphate (DBVP), and dioctyl dichlorovinyl phosphate (DOVP). "
4.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/1993 - "Mammalian in vivo and in vitro studies of technical or commercial grade malathion and its metabolite malaoxon show a pattern of induction of chromosome damage, as measured by chromosome aberrations, sister chromatid exchanges, and micronuclei. "
5.	Pain (Aches) 01/01/2002 - "In the case of malaoxon earwig and green lacewing AChEs were much more sensitive than AChE of the ladybird beetle. " 05/01/2014 - "Furthermore, in both the mutant and susceptible AChEs, Ace2 was significantly less sensitive to eserine, omethoate, and malaoxon than Ace1. " 05/01/2014 - "In vitro functional expression of AChEs reveals that the resistant Ace1 (Ace1R) and Ace2 (Ace2R) were significantly less inhibited by eserine, omethoate, and malaoxon than the susceptible Ace1 (Ace1S) and Ace2 (Ace2S). " 08/27/2010 - "Biochemical characterization of the recombinant proteins supports classification of rBmAChE1, rBmAChE2, and rBmAChE3 as AChEs (E.C.3.1.1.7), as evidenced by (i) substrate preference for acetylthiocholine, (ii) inhibition by eserine, BW284c51, and the organophosphates (OPs) malaoxon and paraoxon, (iii) insensitivity to iso-OMPA, and (iv) rapid hydrolysis of acetyl-beta-methyl-thiocholine. "

Related Drugs and Biologics

1.	Malathion (Karbofos)
2.	Paraoxon (E600)
3.	Trichlorfon (Metrifonate)
4.	Phosphates (Orthophosphate)
5.	Isoflurophate (DFP)
6.	Esterases
7.	Dichlorvos
8.	phenylsaligenin cyclic phosphate (PSCP)
9.	salicyl alcohol (saligenin)
10.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate