purinoceptor P2Y6

expressed in human spleen, placenta, thymus, intestine, and blood leukocytes; amino acid sequence in first source; GenBank X97058

Also Known As:

P2RY6 protein, human; P2Y(6) receptor; P2Y6 receptor; P2Y6 receptors; P2ry6 protein, mouse; P2ry6 protein, rat; pyrimidinergic receptor P2Y, G-protein coupled, 6 protein, human; pyrimidinergic receptor P2Y, G-protein coupled, 6 protein, mouse; pyrimidinergic receptor P2Y, G-protein coupled, 6 protein, rat; receptor, P2Y(6); receptor, P2Y6

Networked: 90 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Purinergic Receptors: 1014
        Purinergic P2 Receptors: 290
        purinoceptor P2Y6: 90
      - Neurotransmitter Receptors: 562
        Purinergic Receptors: 1014
        Purinergic P2 Receptors: 290
        purinoceptor P2Y6: 90

Experts

1.	Robaye, Bernard: 8 articles (01/2022 - 02/2011)
2.	Boeynaems, Jean-Marie: 6 articles (01/2017 - 02/2011)
3.	Nishida, Motohiro: 5 articles (11/2022 - 12/2008)
4.	Nishimura, Akiyuki: 4 articles (11/2022 - 01/2016)
5.	Gendron, Fernand-Pierre: 4 articles (12/2019 - 02/2008)
6.	Jacobson, Kenneth A: 4 articles (10/2017 - 06/2003)
7.	Kurose, Hitoshi: 3 articles (11/2022 - 12/2008)
8.	Shimoda, Kakeru: 3 articles (11/2022 - 06/2017)
9.	Brown, Guy C: 3 articles (02/2022 - 10/2021)
10.	Milde, Stefan: 3 articles (02/2022 - 10/2021)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 10/01/2019 - "The results demonstrated that inhibition of the P2Y6 receptor can generate antiallodynic effects and improved the pathological neuropathic pain-induced oxidative stress. " 10/01/2019 - "The role of P2Y6 receptors in the maintenance of neuropathic pain and its improvement of oxidative stress in rats." 01/01/2019 - "P2Y6 Receptor-Mediated Spinal Microglial Activation in Neuropathic Pain." 10/01/2018 - "However, it's not clear that the role of P2Y6 receptor in the chronic constriction injury (CCI) model of neuropathic pain rats. " 10/01/2018 - "P2Y6 receptor activation is involved in the development of neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats."
2.	Ischemic Stroke 01/01/2020 - "To investigate whether P2Y6 receptor-mediated microglial phagocytosis is beneficial for the debris clearance and functional recovery after ischemic stroke. " 01/01/2020 - "Our results indicate that P2Y6 receptor-mediated microglial phagocytosis plays a beneficial role during the acute stage of ischemic stroke, which can be a therapeutic target for ischemic stroke." 01/01/2022 - "Based on these findings, we conclude that focal ischemic stroke increases vascular sensitivity to UDP-β-S by upregulating P2Y6 receptors on vascular smooth muscle cells while experimental SAH did not induce changes in vasoreactivity in spite of increased P2Y6 receptor expression."
3.	Inflammation (Inflammations) 02/24/2011 - "These studies show an important contribution of P2Y(6) signaling in enhancing vascular inflammation during systemic LPS challenge and implicate the P2Y(6) receptor as a therapeutic target during systemic inflammatory responses." 01/01/2022 - "NTPDase8 protects the intestine from inflammation most probably by limiting the activation of P2Y6 receptors in colonic epithelial cells. " 01/01/2022 - "NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD." 10/11/2021 - "How inflammation causes neuronal loss is unclear, but one potential mechanism is microglial phagocytosis of neurons, which is dependent on the microglial P2Y6 receptor. " 01/01/2013 - "Lastly, pretreating mice with the P2Y6 receptor antagonists (MSR2578) attenuated TcdA/B-induced inflammation and intestinal permeability in an intrarectal toxin exposure model. "
4.	Neoplasms (Cancer) 01/01/2021 - "Therefore, inhibition of the P2Y6 receptor increases the antitumor activities of the NK cells, which may aid in the design of innovative strategies to improve NK cell-based cancer therapy." 01/01/2017 - "Moreover, the expression levels of P2Y6 receptors in GC tissues were correlated to tumor size, differentiation, metastasis to lymph nodes, and the survival rate of the patients with GC. " 05/01/2018 - "UDP is the endogenous agonist of the G protein-coupled P2Y6 receptor (P2Y6R), which may contribute to the formation of a tumor-promoting microenvironment by coordinating resistance to apoptosis. " 01/01/2017 - "Collectively, we conclude that nucleotides activate P2Y6 receptors to suppress GC growth through a novel SOCE/Ca2+/β-catenin-mediated anti-proliferation of GC cells, which is different from the canonical SOCE/Ca2+-induced apoptosis in other tumors." 04/01/2010 - "Our data establish the direct toxic role and anti-cancer activity of UDP in a neuroblastoma cell line, and identify the P2Y(6) receptor as a novel potential target in anti-tumoural therapies. "
5.	Astrocytoma (Pilocytic Astrocytoma) 07/01/2017 - "High-throughput screening (HTS) was used to study the effects of various compounds on human P2Y6 receptors expressed in 1321N1 human astrocytoma cells by monitoring intracellular Ca2+ concentration ([Ca2+]i) levels using an FDSS7000 real-time fluorescence detector. " 08/22/2014 - "Rp-5-OMe-UDPαB (Rp-5-OMe-uridine 5'-O-α-boranodiphosphate) was most potent and selective in inducing intracellular calcium signaling in 1321N1 astrocytoma cells expressing the human P2Y6 receptor. " 09/01/1998 - "We cloned the turkey homologue of the chick p2y3 receptor, which shares high sequence identity (97.6%) with the chick receptor, and we stably expressed this receptor and the rat P2Y6 receptor in 1321N1 human astrocytoma cells. " 06/01/2003 - "2. Cell death was induced in 1321N1 astrocytoma cells permanently expressing the rat P2Y6 receptor by exposure to TNFalpha in the presence of cycloheximide. " 11/01/2021 - "Derivatives of indole carboxamide have been identified as P2Y12 and P2X7 antagonist, as a result, we developed and tested a series of indole derivatives4a-lhaving thiourea moiety as P2Y receptor antagonist by using a fluorescence-based assay to measure the inhibition of intracellular calcium release in 1321N1 astrocytoma cells that had been stably transfected with the P2Y1, P2Y2, P2Y4 and P2Y6 receptors. "

Related Drugs and Biologics

1.	N,N''- 1,4- butanediylbis(N'- (3- isothiocyanatophenyl))thiourea
2.	purinoceptor P2Y6
3.	Matrix Metalloproteinases (MMPs)
4.	Endothelin-1 (Endothelin 1)
5.	Bleomycin (Blenoxane)
6.	Apolipoproteins E (ApoE)
7.	Apolipoproteins
8.	Analgesics (Analgesic Drugs)
9.	Uridine Diphosphate (UDP)
10.	Nucleotides

Related Therapies and Procedures

1.	Therapeutics