Ki antigen

isolated from patients with systemic lupus erythematosus; amino acid sequence

Also Known As:

Ki antigen, mouse; PA28 gamma protein, human; PA28gamma; PSME3 protein, human; Psme3 protein, mouse; REGgamma; pa28g protein, mouse; proteaseome (prosome, macropain) 28 subunit, 3 protein, mouse

Networked: 21 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Biological Factors: 2472
- Antigens: 143924
  - Autoantigens: 7570
    - Ki antigen: 21
Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Multienzyme Complexes: 8
    - Proteasome Endopeptidase Complex: 7107
      - Ki antigen: 21
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Proteasome Endopeptidase Complex: 7107
        Ki antigen: 21
  - Multienzyme Complexes: 8
    - Proteasome Endopeptidase Complex: 7107
      - Ki antigen: 21

Experts

1.	Li, Xiaotao: 2 articles (11/2010 - 06/2007)
2.	Monaco, John J: 2 articles (06/2007 - 03/2004)
3.	Koike, Kazuhiko: 2 articles (02/2007 - 01/2007)
4.	Matsuura, Yoshiharu: 2 articles (02/2007 - 01/2007)
5.	Miyamoto, Hironobu: 2 articles (02/2007 - 01/2007)
6.	Miyamura, Tatsuo: 2 articles (02/2007 - 01/2007)
7.	Moriishi, Kohji: 2 articles (02/2007 - 01/2007)
8.	Moriya, Kyoji: 2 articles (02/2007 - 01/2007)
9.	Murata, Shigeo: 2 articles (02/2007 - 01/2007)
10.	Suzuki, Tetsuro: 2 articles (02/2007 - 01/2007)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2009 - "In present study, we found oncogenicity of MDA-MB-231 cell transfected with REGgamma was enhanced, which might be realized via REGgamma promoting cell growth, inhibiting cell apoptosis, degrading P21 and suppressing activation of NK, suggesting REGgamma promoting tumor growth is a process involving multiple factor mechanisms." 12/01/2008 - "The discovery that REGgamma regulates cell-cycle regulators is consistent with previous studies where REGgamma-deficient mice have shown retardation in body growth, decreased cell proliferation and increased apoptosis, indicating a potential role of REGgamma in cancer development. " 03/01/2014 - "The overexpression of REGgamma enhanced cancer cell proliferations (P < 0.05), promoted more cells into the S+G2/M phase (P < 0.05) and promoted the migration of cancer cells (P < 0.05). " 01/21/2014 - "All these findings strongly imply that the overexpression of PA28gamma resulted from miR-7 downexpression in NSCLC has an important role in promoting cancer cell progress and consequently results in NSCLC growth. " 12/01/2008 - "This review presents an overview of the function of REGgamma, a summary of the current literature, and insight into the possible biological function of REGgamma relating to cancer, viral pathogenesis, and other diseases."
2.	Insulin Resistance 02/01/2007 - "In this study, we examined whether PA28gamma is required for HCV core-induced insulin resistance in vivo. " 02/01/2007 - "We have previously reported that HCV core gene-transgenic (PA28gamma(+/+)CoreTg) mice develop marked insulin resistance and that the HCV core protein is degraded in the nucleus through a PA28gamma-dependent pathway. " 02/01/2007 - "Although there was no significant difference in the glucose tolerance test results among the mice, the insulin sensitivity in PA28gamma(-/-)CoreTg mice was recovered to a normal level in the insulin tolerance test. "
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 02/01/1990 - "Patients with systemic lupus erythematosus (SLE) produce autoantibodies against a variety of nuclear antigens including Ki antigen. " 02/01/1990 - "Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus." 12/01/1989 - "An enzyme-linked immunosorbent assay using the purified Ki antigen was established, and the clinical significance of the anti-Ki antibody in systemic lupus erythematosus (SLE) was studied. " 12/01/1989 - "Purification and characterization of Ki antigen and detection of anti-Ki antibody by enzyme-linked immunosorbent assay in patients with systemic lupus erythematosus."
4.	Infections 01/30/2007 - "These findings suggest that PA28gamma plays a crucial role in the development of liver pathology induced by HCV infection." 11/01/2010 - "Proteasome activator REGgamma enhances coxsackieviral infection by facilitating p53 degradation."
5.	Chromosomal Instability (Chromosome Stability) 02/15/2008 - "These findings thus underscore a previously uncharacterized function of REGgamma in centrosome and chromosomal stability maintenance." 02/15/2008 - "REGgamma proteasome activator is involved in the maintenance of chromosomal stability."

Related Drugs and Biologics

1.	Proteasome Endopeptidase Complex (Proteasome)
2.	Nuclear Antigens (Extractable Nuclear Antigens)
3.	Complementary DNA (cDNA)
4.	Saponins
5.	Messenger RNA (mRNA)
6.	Proteins (Proteins, Gene)
7.	Nuclear Proteins (Protein, Nuclear)
8.	Insulin (Novolin)
9.	Immunosorbents
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation