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4-(2' methoxyphenyl)- 1- (2'- (N- (2''- pyridinyl)- 4- fluorobenzamido)ethyl)piperazine

Also Known As:

4-MPPF; p-MPPF

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - 4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - 4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine: 3
  - Piperazines: 26
    - 4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine: 3

Experts

1.	Huang, W J: 1 article (05/2000)
2.	Lee, C Y: 1 article (05/2000)
3.	Liau, C S: 1 article (05/2000)
4.	Yau, S M: 1 article (05/2000)

Related Diseases

1.	Hypothermia 05/01/1996 - "No hypothermia or reciprocal forepaw treading was produced by either drug when given at doses as high as 10 mg/kg. Neither p-MPPI nor p-MPPF (10 mg/kg) given alone significantly altered the ratio of 5-HIAA/5-HT in the hippocampus or striatum. " 01/01/1995 - "The effects of two putative 5-HT1A antagonists, 4-(2'-methoxyphenyl)-1- [2'-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI) and 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine (p-MPPF), were examined in vivo in two tests of postsynaptic 5-HT1A receptor activation, hypothermia and reciprocal forepaw treading, in the rat. " 05/01/1996 - "p-MPPI [4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido] ethylpiperazine] and p-MPPF [4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine] competitively antagonized 5-HT1A receptor activation in the rat, as measured by hypothermia, forepaw treading and 5-HT turnover; they exhibited to partial agonist activity on any of these measures. "
2.	Hyperglycemia 05/01/2000 - "Finally, ketanserin (a 5-HT(2A) receptor antagonist), but not p-MPPF (a 5-HT(1A) receptor antagonist), GR 55562 (a 5-HT(1B/1D) receptor antagonist), SB 206553 (a 5-HT(2B/2C) receptor antagonist), or tropisetron (a 5-HT(3) receptor antagonist), was able to block 5-HT-induced hyperglycemia. "

Related Drugs and Biologics

1.	5-HT1A Serotonin Receptor
2.	Piperazine
3.	4- (2'- methoxyphenyl)- 1- (2'- (N- (2''- pyridinyl)- 4- iodobenzamido)ethyl)piperazine
4.	Serotonin (5 Hydroxytryptamine)
5.	Ketanserin
6.	Tropisetron (Navoban)
7.	3- (3- (dimethylamino)propyl)- 4- hydroxy- N- (4- (4- pyridinyl)phenyl)benzamide
8.	SB 206553