HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

TAPI-2

analog of TAPI inhibitor with the naphthyl-alanine side chain replaced by a tert-butyl group

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - TAPI-2: 6
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - TAPI-2: 6

Experts

1.	Jia, Naixin: 1 article (01/2021)
2.	Liang, Yi: 1 article (01/2021)
3.	Liu, Jie: 1 article (01/2021)
4.	Luo, Qing: 1 article (01/2021)
5.	Qiao, Wei: 1 article (01/2021)
6.	Tian, Hao: 1 article (01/2021)
7.	Wang, Weiyi: 1 article (01/2021)
8.	Wang, Yuan: 1 article (01/2021)
9.	Yang, Tian: 1 article (01/2021)
10.	Ye, Yu: 1 article (01/2021)

Related Diseases

1.	Necrosis 07/01/2005 - "In vivo treatment with the hydroxamate-based metalloprotease inhibitors BB3103 or TAPI-2 (tumour necrosis factor-alpha protease inhibitor 2) reversibly induced accumulation of forms of proTGFalpha that included the N-terminal extension. " 03/01/2004 - "Hmeprin is inhibited by hydroxamic acid derivatives such as batimastat, galardin and Pro-Leu-Gly-hydroxamate, by TAPI-0 (tumour necrosis factor alpha protease inhibitor-0) and TAPI-2, and by thiol-based compounds such as captopril. "
2.	Hyperplasia 01/01/2021 - "The HNE + TAPI-2 and HNE + AG1478 groups had significantly less goblet cell and submucosal gland hyperplasia as well as weaker PAS staining. "
3.	Breast Neoplasms (Breast Cancer) 06/01/2014 - "Inhibition of TβRIII shedding through treatment with TAPI-2 or expression of a non-shedding TβRIII mutant rescued TβRIII mediated inhibition of BMP induced Smad1/5/8 phosphorylation and BMP induced migration and/or invasion in both in normal mammary epithelial cells and breast cancer cells. "
4.	Astrocytoma (Pilocytic Astrocytoma) 12/08/2009 - "A TP agonist U46619 caused the phosphorylation of EGFR in 1321N1 human astrocytoma cells, which was inhibited by an EGFR selective inhibitor AG1478 and by a disintegrin and metalloproteinase (ADAM) inhibitor TAPI-2, indicating TP stimulation caused the EGFR transactivation through the EGFR ligand shedding. "
5.	Hypoxia (Hypoxemia) 01/01/2021 - "Here, we found that ADAM17 expression and activity were significantly promoted in keratinocytes under hypoxic condition, inhibition of ADAM17 by TAPI-2, or silencing of ADAM17 using small interfering RNA which suppressed the hypoxia-induced migration of keratinocytes significantly, indicating a pivotal role for ADAM17 in keratinocyte migration. "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Protease Inhibitors (Protease Inhibitor)
3.	RTKI cpd
4.	Small Interfering RNA (siRNA)
5.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
6.	Disintegrins
7.	Sulfhydryl Compounds (Thiols)
8.	Ligands
9.	Hydroxamic Acids (Hydroxamic Acid)
10.	Captopril (Capoten)