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trichodimerol

fungal metabolite isolated from Penicillium chrysogenum; structure in first source

Also Known As:

BMS 182123; BMS-182123

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - trichodimerol: 3
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - trichodimerol: 3

Experts

1.	Jiang, Cheng-Shuai: 1 article (06/2015)
2.	Li, Juan: 1 article (06/2015)
3.	Li, Wel-Qi: 1 article (06/2015)
4.	Liu, He-Tao: 1 article (06/2015)
5.	Miao, Zhen-Hua: 1 article (06/2015)
6.	Ya, Wan-Xia: 1 article (06/2015)
7.	Yao, Yao: 1 article (06/2015)
8.	Zhao, Xun-Xia: 1 article (06/2015)
9.	Zheng, Ping: 1 article (06/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Additionally, MAPkinases regulate production of specific secondary metabolites including trichodimerol and bisorbibutenolid, a bioactive compound with cytostatic effect on cancer cells and deterrent effect on larvae, under conditions facilitating mating, which reflects a defect in chemical communication. " 06/01/2015 - "It was found that trichodimerol and sorbicillin exhibited strong cytotoxic activity with IC50 values from 6.55 μM to 28.55 μM on three cancer cell lines, HL-60, U937 and T47D. "
2.	Inflammation (Inflammations) 01/01/2022 - "Hence, trichodimerol inhibits inflammation by obstructing the interaction between LPS and the TLR4-MD2 heterodimer and suppressing the downstream NF-κB and NLRP3 pathways." 01/01/2022 - "Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway." 01/01/2022 - "Western blotting results showed that trichodimerol could inhibit the production of inflammatory mediators such as cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) and the protein expression of nuclear transcription factor-kappaB (NF-κB), p-IKK, p-IκB, Toll-like receptor 4 (TLR4), NOD-like receptor thermal protein domain associated protein 3 (NLRP3), cysteinyl aspartate specific proteinase (Caspase)-1, and ASC, which indicated that trichodimerol may inhibit inflammation through the NF-κB and NLRP3 pathways. "

Related Drugs and Biologics

1.	Cytostatic Agents
2.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
3.	Toll-Like Receptor 4
4.	Transcription Factors (Transcription Factor)
5.	Proteins (Proteins, Gene)
6.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
7.	Peptide Hydrolases (Proteases)
8.	Aspartic Acid (Aspartate)
9.	NLR Proteins
10.	sorbicillin