CMDBS 25

06/01/2001 - "Overall, this study points to the potential use of a combination of CMDB7 and TAM to inhibit tumor angiogenesis that can prevent tumor progression."
06/01/2001 - "Histological analysis showed markedly less neovascularization (88%) in the tumors treated with a combination of CMDB7 and TAM. "
06/01/2001 - "Combined treatments with CMDB7 and TAM block the tumor development by 94% and induce a complete regression of 4 of 8 mice. "
06/01/1998 - "injection of CMDB7 inhibited by 66% the tumor growth of MCF-7ras xenografts in nude mice. "
12/01/1992 - "The effect on MCF7 tumor cells was most apparent with CMDBS. "

01/01/2001 - "In this work, we studied the uptake of CMDB7 labeled with 99mTc in cultured human breast cancer MCF-7 cell line and the highly tumorigenic MCF-7ras cell line (Ha-ras-transfected MCF-7 cells) and the in vivo distribution in MCF-7ras tumor-bearing mice. "
01/01/2001 - "Carboxymethyl Benzylamide Dextran (CMDB7) displayed an in vitro growth inhibitory activity on breast tumor cells. "
01/01/1997 - "These results indicate that CMDB7 can inhibit fibroblast-breast cancer cell interactions possibly by interfering with paracrine growth factor loops."
01/01/2001 - "These results confirm the absence of toxicity of CMDB7 and the usefulness of CMDB7 in cancer therapy by targeting breast tumors."
01/01/1997 - "Modulation of interactions between human breast carcinoma cells (MCF-7ras) and fibroblasts from normal breast tissue (MG3) and from a post-radiation fibrosis with recurrent breast carcinoma (FPR7) by a dextran derivative (CMDB7) was investigated. "

09/12/2022 - "This study showed that combined VNS-CMDBS therapy was able to double the number of responders compared with VNS alone in a cohort of patients with refractory generalized epilepsy. "
09/12/2022 - "A total of 11 consecutive patients with refractory generalized epilepsy (ten with Lennox-Gastaut syndrome) previously submitted to VNS and who subsequently underwent CMDBS were retrospectively studied. "
09/12/2022 - "This article describes our findings while treating patients with refractory generalized epilepsy with combined vagus nerve stimulation (VNS) and centro-median deep brain stimulation (CMDBS). "

01/01/1994 - "Our study pinpoints that some specific CMDBS are as potent agents as bFGF for corneal ulcer healing, and can therefore be proposed for therapeutic use."
01/01/1994 - "The wound healing activity of one specific CMDBS was studied in a model of corneal ulcer on the rabbit eye and compared with the activity of basic fibroblast growth factors (bFGF) added alone or in association with CMDBS. "
01/01/1994 - "CMDBS, functional analogue of heparin sulfate as a new class of corneal ulcer healing agents."

07/07/2003 - "In the present study, we explored the effects of CMDB7 on highly aggressive human epidermoid carcinoma A431 cells known to overexpress epidermal growth factor receptors (EGFRs) and produce a high amount of VEGF and a minor quantity of bFGF. "