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S-4-bromobenzylglutathione cyclopentyl diester

a glyoxylase I inhibitor

Also Known As:

BrBzGSHCp2; S-p-bromobenzylglutathione dicyclopentyl ester

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Glutathione: 14524
      - S-4-bromobenzylglutathione cyclopentyl diester: 2

Related Diseases

1.	Neoplasms (Cancer) 07/01/1995 - "This was accompanied by an increased tolerance for exogenous methylglyoxal and enhanced resistance to the cytotoxic effects of two glyoxalase I inhibitors (s-p-bromobenzylglutathione diethyl ester and s-p-bromobenzylglutathione dicyclopentyl ester), a glutathione analogue [gamma-glutamyl-(S)-(benzyl)cysteinyl-(R)-(-)-phenylglycine diethyl ester] and the anti-cancer drugs mitomycin C and adriamycin. "
2.	Adenocarcinoma 05/17/1996 - "Incubation of HL60 cells with 10 microM BrBzGSHCp2 delivered the diester into cells: de-esterification of the diester there in lead to formation of the S-p-bromobenzylglutathione, inhibition of glyoxalase I activity in situ, increase in the methylglyoxal concentration after 1 hr, and induction of apoptosis after 6 hr. BrBzGSHCp2 (50-200 mg/kg) also inhibited the growth of murine adenocarcinoma 15A in vivo. "

Related Drugs and Biologics

1.	Pyruvaldehyde (Methylglyoxal)
2.	Lactoylglutathione Lyase
3.	Mitomycin (Mitomycin-C)
4.	Glutathione (Reduced Glutathione)
5.	Esters
6.	Doxorubicin (Adriamycin)
7.	S-4-bromobenzylglutathione diethyl ester