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5'-O-(o-carboran-1-ylmethyl)uridine
Also Known As:
CBU-5'
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Inorganic Chemicals: 9
Boron Compounds: 91
5'-O-(o-carboran-1-ylmethyl)uridine: 1
Organic Chemicals: 133
Boron Compounds: 91
5'-O-(o-carboran-1-ylmethyl)uridine: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidine Nucleosides: 50
Uridine: 1186
5'-O-(o-carboran-1-ylmethyl)uridine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Pyrimidine Nucleosides: 50
Uridine: 1186
5'-O-(o-carboran-1-ylmethyl)uridine: 1
Ribonucleosides: 49
Uridine: 1186
5'-O-(o-carboran-1-ylmethyl)uridine: 1
Related Diseases
1.
Brain Neoplasms (Brain Tumor)
01/01/1996 - "
The purpose of the present study was to evaluate 2' and 5'-O-(o-carboran-1-ylmethyl)uridine (CBU-2' and CBU-5') as delivery agents for Boron Neutron Capture Therapy (BNCT) of brain tumors.
"
2.
Glioma (Gliomas)
01/01/1996 - "
However, CBU-2' and CBU-5' were highly toxic for F98 glioma cells in vitro (IC50 = 3 - 13 x 10(-5) M), as determined by measuring the uptake of 3H-thymidine, and the survival of F98 glioma cells using a clonogenic assay, which suggests that these compounds should be further evaluated as potential cytoreductive chemotherapeutic agents.
"
Related Drugs and Biologics
1.
2'-O-(carboran-1-ylmethyl)uridine
Related Therapies and Procedures
1.
Boron Neutron Capture Therapy