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clasto-lactacystin beta-lactone

active metabolite of lactacystin; inhibits 20 S proteasome; structure in first source

Also Known As:

c-lact compound; clasto-lactacystin beta-lactone, (1R-(1alpha(S*),4beta,5alpha))-isomer

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - clasto-lactacystin beta-lactone: 6

Experts

1.	Li, Zhuan: 1 article (06/2009)
2.	Matsubara, Keiko: 1 article (06/2009)
3.	Murayama, Tsugiya: 1 article (06/2009)
4.	Sadanari, Hidetaka: 1 article (06/2009)
5.	Tanaka, Junji: 1 article (06/2009)
6.	Yamada, Rie: 1 article (06/2009)
7.	Dosenko, Victor E: 1 article (01/2009)
8.	Moibenko, Alexey A: 1 article (01/2009)
9.	Nagibin, Vasyl S: 1 article (01/2009)
10.	Surova, Olga V: 1 article (01/2009)

Related Diseases

1.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/2009 - "The B-cell lymphoma 2 gene expression was unaffected by the use of clasto-lactacystin beta-lactone in low dose. "
2.	Thyroid Neoplasms (Thyroid Cancer) 03/01/2003 - "Moreover, the growth of thyroid cancer cell lines was affected by the proteasome inhibitor, clasto-lactacystin beta-lactone. "
3.	Infertility (Sterility) 08/17/1999 - "Specific inhibition of proteasome activity with clasto-lactacystin beta-lactone (CLbetaL) prevented the onset of self-sterility, but had no effect once this process had started. "
4.	Herpes Zoster 05/01/2003 - "Sperm-zona binding was not inhibited by clasto-lactacystin beta-lactone. "
5.	Glioma (Gliomas) 06/01/2009 - "Treatment of HCMV-infected 118MGC glioma and U373-MG astrocytoma cells with three proteasome inhibitors, MG132, clasto-lactacystin beta-lactone, and epoxomicin, suppressed MIE protein expression. "

Related Drugs and Biologics

1.	Proteasome Inhibitors
2.	Proteasome Endopeptidase Complex (Proteasome)
3.	Proteins (Proteins, Gene)
4.	epoxomicin
5.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde