low density lipoprotein receptor-related protein 8

predominantly expressed in brain; RefSeq NM_004631 (human); NM_053073 (mouse)

Also Known As:

APOER2 protein, human; LR7-8B protein, human; LRP8 protein, human; Lrp8 protein, mouse; apoER2 protein, mouse; apolipoprotein E receptor 2; apolipoprotein E receptors 2; apolipoprotein e receptor, human; apolipoprotein e receptor, mouse; low density lipoprotein receptor-related protein 8, human; low density lipoprotein receptor-related protein 8, mouse; receptor 2, apolipoprotein E

Networked: 31 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Lipoprotein Receptors: 240
        LDL Receptors: 3829
        LDL-Receptor Related Proteins: 2
        low density lipoprotein receptor-related protein 8: 31
  - LDL-Receptor Related Proteins: 2
    - low density lipoprotein receptor-related protein 8: 31

Experts

1.	Mineo, Chieko: 6 articles (01/2021 - 09/2014)
2.	Shaul, Philip W: 6 articles (01/2021 - 09/2014)
3.	Herz, Joachim: 5 articles (01/2021 - 09/2014)
4.	Hui, David Y: 5 articles (01/2021 - 09/2014)
5.	Ulrich, Victoria: 5 articles (10/2018 - 09/2014)
6.	Sacharidou, Anastasia: 4 articles (01/2021 - 01/2016)
7.	Salmon, Jane E: 4 articles (10/2018 - 10/2014)
8.	Shen, Yu-Min: 3 articles (10/2018 - 10/2014)
9.	Urbanus, Rolf T: 2 articles (03/2016 - 01/2011)
10.	de Groot, Philip G: 2 articles (03/2016 - 01/2011)

Related Diseases

1.	Myocardial Infarction 02/01/2009 - "Our group has previously reported genetic studies associating polymorphisms in the low density lipoprotein receptor related protein 8 (LRP8) gene with myocardial infarction. " 05/13/2009 - "The R952Q variant in the low density lipoprotein receptor-related protein 8 (LRP8)/apolipoprotein E receptor 2 (ApoER2) gene has been recently associated with familial and premature myocardial infarction (MI) by means of genome-wide linkage scan/association studies. "
2.	Thrombosis (Thrombus) 01/01/2016 - "We previously discovered that aPL recognition of cell surface β2-glycoprotein I (β2-GPI) initiates apolipoprotein E receptor 2 (apoER2)-dependent signaling in endothelial cells and in placental trophoblasts that ultimately promotes thrombosis and fetal loss, respectively. " 08/01/2008 - "Previous work has shown that binding of dimeric beta(2)-GPI to the platelet receptors apolipoprotein E receptor 2' (ApoER2') and glycoprotein Ibalpha (GPIbalpha) mediates increased platelet activation in an in vitro thrombosis model. " 01/27/2011 - "We investigated the role of Apolipoprotein E receptor 2 (ApoER2') on the pathogenic effects of a patient-derived polyclonal aPL IgG preparation (IgG-APS), a murine anti-β(2)GPI monoclonal antibody (E7) and of a constructed dimeric β(2)GPI I (dimer), which in vitro mimics β(2)GPI-antibody immune complexes, using an animal model of thrombosis, and ApoER2-deficient (-/-) mice. " 10/01/2018 - "In the antiphospholipid syndrome (APS), antiphospholipid antibody (aPL) recognition of β2 glycoprotein I promotes thrombosis, and preclinical studies indicate that this is due to endothelial nitric oxide synthase (eNOS) antagonism via apolipoprotein E receptor 2 (apoER2)-dependent processes. " 12/01/2017 - "On the other hand, platelets may have a key role in APS-related thrombosis due to the presence of multiple receptors that can interact with anti-β2-GPI antibodies (especially apolipoprotein E receptor 2' (apoER2') and glycoprotein Ibα (GPIbα)) with consequent release of different procoagulant mediators such as thromboxane B2, platelet factor 4 (PF4), and platelet factor 4 variant (CXCL4L1). "
3.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 10/14/2014 - "The initiating process entails NO deficiency mediated by β2-glycoprotein I recognition by aPLs and apolipoprotein E receptor 2. The modulation of endothelial apolipoprotein E receptor 2 function or NO bioavailability may represent new interventions to prevent the nonthrombotic vascular occlusion and resulting cardiovascular disorders that afflict antiphospholipid syndrome patients." 01/27/2011 - "Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome." 10/01/2018 - "In the antiphospholipid syndrome (APS), antiphospholipid antibody (aPL) recognition of β2 glycoprotein I promotes thrombosis, and preclinical studies indicate that this is due to endothelial nitric oxide synthase (eNOS) antagonism via apolipoprotein E receptor 2 (apoER2)-dependent processes. "
4.	Neoplasms (Cancer) 08/10/2022 - "Among the receptors in the family, recent studies place low-density lipoprotein receptor-related protein 8 (LRP8) at the center of both neurodegenerative and cancer-related pathways. " 08/10/2022 - "Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration." 01/01/2022 - "Low-density lipoprotein receptor-related protein 8 (LRP8) is involved in the development of multiple tumors, including lung cancer. " 01/01/2019 - "In addition to its role in cancer progression, LRP8 (apolipoprotein E receptor 2 [APOER2]) has also been demonstrated to regulate canonical Wnt/β-catenin signaling pathway whereby this pathway plays a role in cell migration and development. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 10/01/2019 - "Genome-wide studies showed that mutation in apoER2 (apolipoprotein E receptor-2) is additive with ε4 polymorphism in the APOE gene on cardiovascular disease risk in humans. " 07/12/2020 - "Low-density lipoprotein receptor-related protein 8 (LRP8) or Apolipoprotein E receptor 2 (ApoER2), is expressed by macrophages, endothelial cells and platelets and has been implicated in the development of cardiovascular diseases. " 09/16/2014 - "It is poorly understood why there is greater cardiovascular disease risk associated with the apolipoprotein E4 (apoE) allele vs. apoE3, and also greater risk with the LRP8/apolipoprotein E receptor 2 (ApoER2) variant ApoER2-R952Q. "

Related Drugs and Biologics

1.	low density lipoprotein receptor-related protein 8
2.	Apolipoproteins E (ApoE)
3.	Glycoproteins (Glycoprotein)
4.	LDL Receptors (LDL Receptor)
5.	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)
6.	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)
7.	Antiphospholipid Antibodies
8.	Proteins (Proteins, Gene)
9.	VLDL Lipoproteins
10.	Catenins