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adenylyl- (2'- 5')- adenylyl- (2'- 2'')- 9- ((2'- hydroxyethoxy)methyl)adenine
structure in first source
Also Known As:
AA-etherA
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleotides: 140
Adenine Nucleotides: 1066
adenylyl-(2'-5')-adenylyl-(2'-2'')-9-((2'-hydroxyethoxy)methyl)adenine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleotides: 15763
Ribonucleotides: 307
Adenine Nucleotides: 1066
adenylyl-(2'-5')-adenylyl-(2'-2'')-9-((2'-hydroxyethoxy)methyl)adenine: 1
Purine Nucleotides: 140
Adenine Nucleotides: 1066
adenylyl-(2'-5')-adenylyl-(2'-2'')-9-((2'-hydroxyethoxy)methyl)adenine: 1
Related Diseases
1.
Neoplasms (Cancer)
02/15/1996 - "
These data indicate that 2-5A analogs, particularly bifunctional 2-5A analogs like AA-etherA, will be useful for controlling cancer cell growth.
"
2.
Breast Neoplasms (Breast Cancer)
02/15/1996 - "
AA-etherA inhibits DNA replication and cell division of both estrogen receptor positive (MCF-7) and estrogen receptor negative (BT-20) breast cancer cells in culture in a dose-dependent manner.
"
02/15/1996 - "
The design, chemical synthesis and biological activities of a nuclease-resistant, nontoxic bioactive 2-5A derivative, AA-etherA [i.e., adenylyl-(2'-5')-adenylyl-(2'-2")-9-[(2'-hydroxyethoxy)-methyl]adenine], are described as a new approach to the inhibition of breast cancer cell growth.
"
02/15/1996 - "
Inhibition of growth of estrogen receptor positive and estrogen receptor negative breast cancer cells in culture by AA-etherA, a stable 2-5A derivative.
"
Related Drugs and Biologics
1.
Estrogen Receptors
2.
Adenine