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1192U90
structure given in first source
Also Known As:
2-amino-N-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)benzamide hydrochloride
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
1192U90: 1
Piperazines: 26
1192U90: 1
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
1192U90: 1
Related Diseases
1.
Schizophrenia (Dementia Praecox)
09/01/1996 - "
The results suggest that 1192U90 would be effective for positive and negative symptoms of schizophrenia, with minimal liability for EPSs, and may also have anxiolytic properties.
"
09/01/1996 - "
1192U90 was developed on the assumption that antagonism of 5-HT2 receptors efficacy yields more potently than D2 receptors against positive and negative symptoms of schizophrenia with minimal liability for extrapyramidal side effects (EPSs), and that 5-HT1A agonism further reduces EPSs and provides anxiolytic and antidepressant activity.
"
2.
Catalepsy
09/01/1996 - "
1192U90 was submitted to four tests that predict antipsychotic efficacy (antagonism of apomorphine-induced climbing in mouse, antagonism of apomorphine-induced circling in rats with unilateral 6-OHDA lesions, antagonism of amphetamine-induced hyperlocomotion in rat, and inhibition of conditioned avoidance in rat), two tests of 5-HT2 function (antagonism of 5-MeODMT-induced head twitches in mouse and antagonism of 5-HTP-induced wet dog shakes in rat), and three tests that predict EPS liability (antagonism of apomorphine-induced stereotypy in mouse and rat and induction of catalepsy in mouse).
"
Related Drugs and Biologics
1.
Anti-Anxiety Agents (Anxiolytics)
2.
Antipsychotic Agents (Antipsychotics)
3.
Apomorphine
4.
Antidepressive Agents (Antidepressants)
5.
Amphetamine (Amfetamine)