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MAP-kinase-activated kinase 3

substrate of CSBP p38 MAP kinase; has about 70% amino acid identity with MAPKAP kinase-2, located in the small cell lung cancer tumor suppressor gene region; RefSeq NM_004635
Also Known As:
MAPKAP kinase-3; MAPKAPK3; MAPKAPK3 protein, human; MK3.1 protein, mouse; MK3.2 protein, mouse; Mapkapk3 protein, mouse; Mapkapk3 protein, rat; mitogen-activated protein kinase-activated protein kinase 3, human; mitogen-activated protein kinase-activated protein kinase 3, mouse; mitogen-activated protein kinase-activated protein kinase 3, rat; mitogen-activated protein kinase-activated protein kinase-3
Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Azuma, Nobuyoshi: 2 articles (01/2020 - 01/2013)
2. Saito, Yukihiro: 2 articles (01/2020 - 01/2013)
3. Sasajima, Tadahiro: 2 articles (01/2020 - 01/2013)
4. Gaestel, Matthias: 2 articles (03/2016 - 02/2015)
5. Babel, Ingrid: 2 articles (08/2012 - 10/2009)
6. Barderas, Rodrigo: 2 articles (08/2012 - 10/2009)
7. Casal, J Ignacio: 2 articles (08/2012 - 10/2009)
8. Díaz-Uriarte, Ramón: 2 articles (08/2012 - 10/2009)
9. Fan, Yajuan: 1 article (04/2022)
10. Gao, Fengjie: 1 article (04/2022)

Related Diseases

1. Glioma (Gliomas)
2. Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
3. Neoplasms (Cancer)
10/01/2009 - "Five immunoreactive antigens, PIM1, MAPKAPK3, STK4, SRC, and FGFR4, showed the highest prevalence in cancer samples, whereas ACVR2B was more abundant in normal sera. "
08/03/2012 - "A combination of three phages displaying peptides homologous to GRN, NHSL1 and SREBF2 and four proteins PIM1, MAPKAPK3, FGFR4 and ACVR2B, achieved an area under the curve (AUC) of 94%, with a sensitivity of 89.1% and specificity of 90.0%, to correctly predict the presence of cancer. "
01/01/2019 - "However, for colorectal cancer we present the detection of four tumor-associated antigen (TAA) biomarkers (MAPKAPK3, PIM-1, STK4, and GTF2B) as possible TAA targets for autoantibody production. "
02/18/2015 - "Here we show that two related stress-responsive kinases, members of the p38 mitogen-activated protein kinase (MAPK) signaling pathway MAPKAPK2 (MK2) and MAPKAPK3 (MK3), positively regulate starvation-induced autophagy by phosphorylating an essential ATG protein, Beclin 1, at serine 90, and that this phosphorylation site is essential for the tumor suppressor function of Beclin 1. Moreover, MK2/MK3-dependent Beclin 1 phosphorylation (and starvation-induced autophagy) is blocked in vitro and in vivo by BCL2, a negative regulator of Beclin 1. Together, these findings reveal MK2/MK3 as crucial stress-responsive kinases that promote autophagy through Beclin 1 S90 phosphorylation, and identify the blockade of MK2/3-dependent Beclin 1 S90 phosphorylation as a mechanism by which BCL2 inhibits the autophagy function of Beclin 1. "
4. 5 Familial Hemophagocytic Lymphohistiocytosis
5. Triple Negative Breast Neoplasms

Related Drugs and Biologics

1. Mitogen-Activated Protein Kinases
2. MAP-kinase-activated kinase 2
3. p38 Mitogen-Activated Protein Kinases
4. Proteins (Proteins, Gene)
5. Protein Kinases (Protein Kinase)
6. Phosphotransferases (Kinase)
7. Antigens
8. Mitogen-Activated Protein Kinase 14
9. Biomarkers (Surrogate Marker)
10. Serine (L-Serine)

Related Therapies and Procedures

1. Therapeutics