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4-aminoimidazole

structure in first source

Also Known As:

5-aminoimidazole

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 4-aminoimidazole: 8

Experts

1.	Dong, Yu-Gang: 2 articles (10/2009 - 04/2007)
2.	Liu, Dan: 2 articles (10/2009 - 04/2007)
3.	Yin, Ran: 2 articles (10/2009 - 04/2007)
4.	Chen, Xiaoxi: 1 article (01/2019)
5.	Gotoh, Noriko: 1 article (01/2019)
6.	Horike, Shin-Ichi: 1 article (01/2019)
7.	Igarashi, Kaori: 1 article (01/2019)
8.	Kato, Keiko: 1 article (01/2019)
9.	Kita, Kenji: 1 article (01/2019)
10.	Kohno, Susumu: 1 article (01/2019)

Related Diseases

1.	Cardiomegaly (Heart Hypertrophy) 04/01/2007 - "To examine the effects of AMPK activation in the development of pressure overload-induced cardiac hypertrophy, we administered 5-aminoimidazole 1 carboxamide ribonucleoside (AICAR, 0.5 mg/g body wt), a specific activator of AMPK, to rats with transaortic constriction (TAC) for 7 weeks. " 10/12/2009 - "Treatment of TAC animals with 5-aminoimidazole 1 carboxamide ribonucleoside (AICAR, 0.5 mg/g body wt), a specific activator of AMPK, inhibited cardiac hypertrophy in TAC and reversed PPARalpha, CPT-I and MCAD expression and fatty acid oxidation. "
2.	Carcinogenesis 01/01/2019 - "MTHFD2 knockdown greatly reduced tumorigenesis and stem-like properties, which were associated with purine nucleotide deficiency, and caused marked accumulation of 5-aminoimidazole carboxamide ribonucleotide (AICAR)-the final intermediate of the purine synthesis pathway. "
3.	Starvation 02/01/1985 - "The mutant exhibited many of the predicted consequences of a decreased PRPP pool and a defective PRPP synthetase enzyme, including: poor growth on purine bases; decreased accumulation of 5-aminoimidazole ribonucleotide (the substrate of the blocked purE reaction) under conditions of purine starvation; excretion of anthranilic acid when grown in medium lacking tryptophan; increased resistance to inhibition by 5-fluorouracil; derepressed levels of aspartate transcarbamylase and orotate phosphoribosyltransferase, enzymes involved in the pyrimidine de novo biosynthetic pathway; growth stimulation by PRPP-sparing compounds (e.g. "
4.	Obesity 05/01/2008 - "To identify critical cellular mediators of ovarian responses to obesity induced insulin resistance, DIO females were treated for 4 d before mating with an insulin-sensitizing pharmaceutical: glucose and lipid-lowering AMP kinase activator, 5-aminoimidazole 4-carboxamide-riboside, 30 mg/kg.d; sodium salicylate, IkappaK inhibitor that reverses insulin resistance, 50 mg/kg.d; or peroxisome proliferator activated receptor-gamma agonist rosiglitazone, 10 mg/kg.d. "
5.	Neoplasms (Cancer) 12/14/2017 - "Inhibition of AICARFT with compound 28a results in dramatic elevation of 5-aminoimidazole 4-carboxamide ribonucleotide (ZMP) and growth inhibition in NCI-H460 and MDA-MB-231met2 cancer cell lines. "

Related Drugs and Biologics

1.	AICA ribonucleotide (ZMP)
2.	Ribonucleotides
3.	purine
4.	Cyclin-Dependent Kinase 5
5.	PPAR alpha
6.	Tryptophan (L-Tryptophan)
7.	Sodium Salicylate (Salicylate, Sodium)
8.	Ribose-Phosphate Pyrophosphokinase (Phosphoribosyl Pyrophosphate Synthetase)
9.	Phenformin (Fenformin)
10.	Orotate Phosphoribosyltransferase