trensox

structure given in first source

Also Known As:

O-trensox; tris-N-(2-(8-hydroxyquinoline-5-sulfonato-7-carboxamido)ethyl)amine; tris-N-(2-aminoethyl-(8-hydroxyquinoline-5-sulphonato-7-carboxamido))amine

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - trensox: 6
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Hydroxyquinolines: 9
        trensox: 6

Experts

1.	Brissot, Pierre: 2 articles (12/2006 - 07/2006)
2.	Gaboriau, François: 2 articles (12/2006 - 07/2006)
3.	Lescoat, Gérard: 2 articles (12/2006 - 07/2006)
4.	Pasdeloup, Nicole: 2 articles (12/2006 - 07/2006)
5.	Pierre, Jean-Louis: 2 articles (12/2006 - 07/2006)
6.	Laupen-Chassay, Cindy: 1 article (12/2006)
7.	Chantrel-Groussard, Karine: 1 article (07/2006)
8.	Havouis, René: 1 article (07/2006)
9.	Nick, Hanspeter: 1 article (07/2006)
10.	Buss, Joan L: 1 article (06/2003)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 07/17/2006 - "Moreover, the two chelators exhibit some cytotoxic effect in the two culture models; ICL670A was more cytotoxic than O-trensox and higher concentrations of the two chelators were necessary to induce a cytotoxicity in primary cultures versus hepatoma cells. " 05/01/2000 - "Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines." 07/17/2006 - "By comparing the antiproliferative effect of the iron chelators ICL670A and O-trensox in the human hepatoma cell line HUH7 and human hepatocyte cultures, we have shown that ICL670A decreased cell viability, inhibited DNA replication and induced DNA fragmentation more efficiently than O-trensox. " 12/01/2006 - "The antiproliferative effects of the iron chelator O-trensox and the ornithine-decarboxylase (ODC) inhibitor alpha-difluoromethylornithine (DFMO) were characterized in the rat hepatoma cell line FAO, the rat liver epithelial cell line (RLEC) and the primary rat hepatocyte cultures stimulated by EGF. "
2.	Neoplasms (Cancer) 06/01/2003 - "The anti-tumor activity of the PIH analogs and other chelators such as tachpyridine, O-trensox and the desferrithiocin analogs have been well characterized in vitro. " 06/01/2003 - "Examples of iron chelators that have shown promising anti-tumor activity (in various stages of development) include heterocyclic carboxaldehyde thiosemicarbazones, analogs of pyridoxal isonicotinoyl hydrazone, tachpyridine, O-trensox, desferrithiocin, and other natural and synthetic chelators. "
3.	Hepatoblastoma 05/01/2000 - "We investigated the effects of a new iron chelator, O-Trensox (TRX), compared with desferrioxamine (DFO), on proliferation and apoptosis in cultures of the human hepatoblastoma HepG2 and hepatocarcinoma HBG cell lines. "
4.	Hypochromic Anemia (Chlorosis) 12/15/1995 - "In spite of its high and specific affinity for iron, O-Trensox was found to be able to prevent, and to reverse, iron chlorosis in several plant species grown in axenic conditions. "

Related Drugs and Biologics

1.	Iron
2.	Chelating Agents
3.	tachpyr
4.	desferrithiocin
5.	Thiosemicarbazones
6.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
7.	Epidermal Growth Factor (EGF)
8.	Deferoxamine (Desferal)
9.	Eflornithine (Ornidyl)
10.	Deferasirox