interleukin-24 (ST16)

a melanoma differentiation associated gene product; forced expression of mda-7 in human melanoma cells suppresses growth and colony formation; MW 23.8 kDa; amino acid sequence given in first source; GenBank U16261 (human); RefSeq NM_006850 (human)

Also Known As:

ST16; FISP; C49A protein, human; FISP protein, human; IL-24 protein; IL-24 protein, human; IL10B; IL24 protein, human; MDA-7 protein, human; MOB-5 protein, human; Mob-5; ST16 protein, human; Suppression of tumorigenicity 16 protein, human; interleukin 24, human; mda-7 protein; melanoma differentiation associated protein 7; melanoma differentiation association protein 7; suppression of tumorigenicity 16 protein

Networked: 271 relevant articles (12 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chada, Sunil: 19 articles (06/2015 - 02/2002)
2.	Ramesh, Rajagopal: 15 articles (06/2015 - 08/2003)
3.	Yang, Jicheng: 12 articles (01/2019 - 06/2008)
4.	Grimm, Elizabeth A: 11 articles (02/2011 - 02/2002)
5.	Xie, Yufeng: 8 articles (01/2019 - 06/2008)
6.	Sheng, Weihua: 7 articles (02/2014 - 06/2008)
7.	Ekmekcioglu, Suhendan: 7 articles (02/2011 - 02/2002)
8.	Xiang, Jim: 6 articles (09/2013 - 06/2008)
9.	Mhashilkar, Abner M: 6 articles (02/2006 - 08/2003)
10.	Miao, Jingcheng: 5 articles (01/2018 - 02/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Previous studies have shown that interleukin-24 (IL-24) has tumor-suppressing activity by multiple pathways. " 06/01/2008 - "Previous studies have shown that interleukin-24 (IL-24; mda-7) as a novel tumor suppressor gene has tumor-suppressive activity against a broad spectrum of human cancers. " 12/01/2004 - "This study defines a tumor-selective cytotoxic bystander role for secreted MDA-7 protein and identifies a novel receptor-mediated, STAT3-independent, and PKR-independent death pathway." 03/01/2004 - "In this study, we sought to determine whether the intracellular or secreted MDA-7 protein was responsible for anti-tumor activity in H1299 lung tumor cells. " 08/01/1999 - "Patient studies showed that the PSIF sequence variant demarcates many tumors not detectable by either FISP or true-FISP. "
2.	Hepatocellular Carcinoma (Hepatoma) 09/07/2015 - "Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells." 07/25/1992 - "[Dynamic 3DFT FISP MR imaging of hepatocellular carcinoma]." 10/01/2013 - "In this study, we assessed the efficacy of combination therapy using AAV-mediated co-expression of apoptin and interleukin-24 on hepatocellular carcinoma in vitro and in vivo. " 10/01/2013 - "The efficacy of combination therapy using adeno-associated virus-mediated co-expression of apoptin and interleukin-24 on hepatocellular carcinoma." 07/25/1992 - "Dynamic 3 dimensional Fourier transformation (3DFT) FISP MR imaging was performed in 5 patients with hepatocellular carcinoma before partial hepatectomy. "
3.	Melanoma (Melanoma, Malignant) 10/01/2001 - "We have designed this study to investigate MDA-7 protein expression in different stages of melanoma progression and to examine its antiproliferative effects in vitro. " 01/01/2020 - "Interleukin-24 (IL-24) is a therapeutic gene for melanoma, which can induce melanoma cell apoptosis. " 01/01/2019 - "Our data suggest that IFN-β suppresses the proliferation of melanoma cells through extracellular IL-24 protein derived from melanoma cells." 12/01/2017 - "Melanoma differentiation-associated gene-7 (MDA-7), also termed interleukin-24, is a potent tumor suppressor gene. " 12/12/2007 - "Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells."
4.	Thrombosis (Thrombus) 12/01/2007 - "The results of the present study show that the true FISP sequence is useful in diagnosing portal vein thrombosis. " 12/01/2007 - "True FISP imaging had a sensitivity of 67% and a specificity of 100% for the diagnosis of portal vein thrombosis. " 12/01/2007 - "Four patients with portal vein thrombosis were accurately diagnosed on the true FISP sequence. " 12/01/2007 - "Magnetic resonance portal venography: use of fast-acquisition true FISP imaging in the detection of portal vein thrombosis." 03/01/1999 - "42 rats in groups of 7 each were examined on days 1, 3, 5, 7, 9 and 11, respectively, after mechanical/chemical thrombus induction in a 1.5 Tesla magnet with a FISP sequence (TR/TE/FA 50 ms/6 ms/40 degrees). "
5.	Venous Thrombosis (Deep-Vein Thrombosis) 12/01/2007 - "Twenty-four consecutive patients with suspected portal venous thrombosis underwent contrast-enhanced 3D MR angiography and true FISP imaging of the portal vein. " 12/01/2005 - "True FISP images should not be used exclusively for the diagnosis of venous thrombosis." 12/01/2005 - "Is true FISP imaging reliable in the evaluation of venous thrombosis?" 08/01/2001 - "The presented high resolution True-FISP MR-venography is a promising non-invasive, fast MR-venography approach for detection of deep venous thrombosis." 08/01/2001 - "A new fast MR-venography approach using a high resolution True-FISP imaging sequence was investigated in 20 patients suffering from 23 deep vein thromboses. "

Related Drugs and Biologics

1.	Cytokines
2.	Gadolinium
3.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
4.	Hydrogen Peroxide (Hydroperoxide)
5.	Endothelial Growth Factors
6.	Gadolinium DTPA (Magnevist)
7.	Messenger RNA (mRNA)
8.	RNA (Ribonucleic Acid)
9.	ferric oxide (iron oxide)
10.	Tocotrienols

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Ventriculostomy
4.	Hepatectomy
5.	Investigational Therapies (Experimental Therapy)